N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-[2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-2-thiophenesulfonamide

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Chemical Name:N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-[2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-2-thiophenesulfonamide
CAS No.:1089669-32-8
Molecular Formula:C₂₃H₂₃N₃O₆S₄
Molecular Weight:565.716
Hs Code.:

Synonyms:N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-[2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-2-thiophenesulfonamide

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Chemical Property of N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-[2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-2-thiophenesulfonamide

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Technology Process of N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-[2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-2-thiophenesulfonamide

There total 11 articles about N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-[2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-2-thiophenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1014613-31-0
benzenesulfonyl-2-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine

: 1089669-31-7
5-bromo-N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-2-thiophenesulfonamide

: 1089669-32-8
N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-[2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-2-thiophenesulfonamide

Guidance literature:: With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 150 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 1072-72-6
Tetrahydrothiopyran-4-one

: 1089669-32-8
N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-[2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-2-thiophenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 56 h / Heating / reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 - 25 °C / Heating / reflux

2.2: 20 °C

3.1: sodium hydroxide / 1,4-dioxane; water / 2 h / 20 - 30 °C

4.1: Oxone / methanol; water / 2 h / 0 - 10 °C

5.1: hydrogenchloride / 1,4-dioxane; water / 20 - 25 °C

6.1: triethylamine / dichloromethane / 20 °C

7.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.5 h / 150 °C / Microwave irradiation

With hydrogenchloride; Oxone; sodium hydroxide; lithium aluminium tetrahydride; hydroxylamine hydrochloride; sodium acetate; sodium carbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water;

Reference yield:

: 6309-59-7
tetrahydro-4H-thiopyran-4-one oxime

: 1089669-32-8
N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-[2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-2-thiophenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 - 25 °C / Heating / reflux

1.2: 20 °C

2.1: sodium hydroxide / 1,4-dioxane; water / 2 h / 20 - 30 °C

3.1: Oxone / methanol; water / 2 h / 0 - 10 °C

4.1: hydrogenchloride / 1,4-dioxane; water / 20 - 25 °C

5.1: triethylamine / dichloromethane / 20 °C

6.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.5 h / 150 °C / Microwave irradiation

With hydrogenchloride; Oxone; sodium hydroxide; lithium aluminium tetrahydride; sodium carbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;