(S)-tert-butyl 4-(2-fluoro-5-nitrophenyl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-ylidenecarbamate

Base Information

Chemical Name:(S)-tert-butyl 4-(2-fluoro-5-nitrophenyl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-ylidenecarbamate
CAS No.:1254199-54-6
Molecular Formula:C₁₇H₂₁FN₄O₅
Molecular Weight:380.376
Hs Code.:

Synonyms:(S)-tert-butyl 4-(2-fluoro-5-nitrophenyl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-ylidenecarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-tert-butyl 4-(2-fluoro-5-nitrophenyl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-ylidenecarbamate

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Technology Process of (S)-tert-butyl 4-(2-fluoro-5-nitrophenyl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-ylidenecarbamate

There total 9 articles about (S)-tert-butyl 4-(2-fluoro-5-nitrophenyl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-ylidenecarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: C₁₁H₁₃FN₂O₄*ClH

: 887913-52-2
(methylamino)thioxomethylcarbamic acid t-butyl ester

: 1254199-54-6
(S)-tert-butyl 4-(2-fluoro-5-nitrophenyl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-ylidenecarbamate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; for 18h;
DOI:10.1021/acs.jmedchem.6b00307

Reference yield:

: 1213413-42-3
(S)-3-amino-3-(2-fluoro-5-nitro-phenyl)-butyric acid methyl ester

: 887913-52-2
(methylamino)thioxomethylcarbamic acid t-butyl ester

: 1254199-54-6
(S)-tert-butyl 4-(2-fluoro-5-nitrophenyl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-ylidenecarbamate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 45 ℃; for 18h;

Reference yield:

: 79110-05-7
1-(2-fluoro-5-nitrophenyl)ethanone

: 1254199-54-6
(S)-tert-butyl 4-(2-fluoro-5-nitrophenyl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-ylidenecarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 18 h / 75 °C / Inert atmosphere

1.2: 0.5 h / 20 °C

2.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexanes / -78 °C

2.2: -78 °C

2.3: -78 °C

3.1: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 0.5 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 45 °C

With hydrogenchloride; titanium(IV) tetraethanolate; n-butyllithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; hexanes; dichloromethane; N,N-dimethyl-formamide;