(S)-tert-butyl 4-(5-amino-2-fluorophenyl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-ylidenecarbamate

Base Information

Chemical Name:(S)-tert-butyl 4-(5-amino-2-fluorophenyl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-ylidenecarbamate
CAS No.:1254199-70-6
Molecular Formula:C₁₇H₂₃FN₄O₃
Molecular Weight:350.393
Hs Code.:

Synonyms:(S)-tert-butyl 4-(5-amino-2-fluorophenyl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-ylidenecarbamate

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Chemical Property of (S)-tert-butyl 4-(5-amino-2-fluorophenyl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-ylidenecarbamate

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Technology Process of (S)-tert-butyl 4-(5-amino-2-fluorophenyl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-ylidenecarbamate

There total 11 articles about (S)-tert-butyl 4-(5-amino-2-fluorophenyl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-ylidenecarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1254199-54-6
(S)-tert-butyl 4-(2-fluoro-5-nitrophenyl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-ylidenecarbamate

: 1254199-70-6
(S)-tert-butyl 4-(5-amino-2-fluorophenyl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-ylidenecarbamate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 29h; under 760.051 Torr;

Reference yield:

: 79110-05-7
1-(2-fluoro-5-nitrophenyl)ethanone

: 1254199-70-6
(S)-tert-butyl 4-(5-amino-2-fluorophenyl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-ylidenecarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 18 h / 75 °C / Inert atmosphere

1.2: 0.5 h / 20 °C

2.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexanes / -78 °C

2.2: -78 °C

2.3: -78 °C

3.1: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 0.5 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 45 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / 29 h / 20 °C / 760.05 Torr

With hydrogenchloride; titanium(IV) tetraethanolate; n-butyllithium; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; hexanes; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1254199-42-2
methyl (S)-3-(((R)-tert-butylsulfinyl)amino)-3-(2-fluoro-5-nitrophenyl)butanoate

: 1254199-70-6
(S)-tert-butyl 4-(5-amino-2-fluorophenyl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-ylidenecarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 0.5 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 45 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 29 h / 20 °C / 760.05 Torr

With hydrogenchloride; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;