Technology Process of 1,3-dichloro-2-(2,2,2-trifluoroethoxy)benzene
There total 4 articles about 1,3-dichloro-2-(2,2,2-trifluoroethoxy)benzene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
isopentyl nitrite;
In
tetrahydrofuran;
for 6h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: hydrogenchloride; sodium nitrite / water / 0 °C
2: ethyl 2-oxocyclohexane carboxylate; caesium carbonate; copper(I) bromide / dimethyl sulfoxide / 18 h / 80 °C / Inert atmosphere
3: hydrogenchloride; tin(ll) chloride / water; methanol / 20 °C
4: isopentyl nitrite / tetrahydrofuran / 6 h / Reflux
With
hydrogenchloride; caesium carbonate; ethyl 2-oxocyclohexane carboxylate; tin(ll) chloride; copper(I) bromide; sodium nitrite; isopentyl nitrite;
In
tetrahydrofuran; methanol; water; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: ethyl 2-oxocyclohexane carboxylate; caesium carbonate; copper(I) bromide / dimethyl sulfoxide / 18 h / 80 °C / Inert atmosphere
2: hydrogenchloride; tin(ll) chloride / water; methanol / 20 °C
3: isopentyl nitrite / tetrahydrofuran / 6 h / Reflux
With
hydrogenchloride; caesium carbonate; ethyl 2-oxocyclohexane carboxylate; tin(ll) chloride; copper(I) bromide; isopentyl nitrite;
In
tetrahydrofuran; methanol; water; dimethyl sulfoxide;
