62778-19-2

Usage

Uses

Used in Pharmaceutical Industry:
3,5-Dichloro-4-iodonitrobenzene is used as an intermediate in the synthesis of various pharmaceuticals for its unique chemical properties that contribute to the development of new drugs.
Used in Dye and Pigment Industry:
3,5-Dichloro-4-iodonitrobenzene is utilized as a precursor in the production of dyes and pigments, where its chemical structure imparts specific color characteristics and properties to the final products.

Upstream product

• 99-30-9 4-nitro-2,6-dichloroaniline 
• 7681-11-0 potassium iodide 
• 401631-95-6 C₁₀H₁₂Cl₂N₄O₂ 

Downstream Products

• 19230-28-5 1,3-dichloro-2-iodobenzene 
• 60962-92-7 1,3-dichloro-2-(4-methoxyphenoxy)-5-nitrobenzene 
• 60963-18-0 3,5-dichloro-4-(4-methoxyphenoxy)aniline 
• 367953-34-2 3,5-dichloro-4-(4-methoxy-phenoxy)-benzaldehyde 
• 355377-58-1 3,5-dichloro-4-(4-methoxy-phenoxy)-benzonitrile 
• 1437779-37-7 5-(5-(3,5-dichloro-4-(2,2,2-trifluoroethoxy)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol 
• 57946-62-0 3,5-dichloro-4-(2,2,2-trifluoroethoxy)aniline 
• 1437779-77-5 1,3-dichloro-2-(2,2,2-trifluoroethoxy)benzene 
• 1437779-78-6 2-(3,5-dichloro-4-(2,2,2-trifluoroethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1437779-79-7 1,3-dichloro-2-(2,2,2-trifluoroethoxy)-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene 
• 1437779-76-4 1,3-dichloro-5-nitro-2-(2,2,2-trifluoroethoxy)benzene 
• 1533425-16-9 1,3-dichloro-2-cyclopropyl-5-nitrobenzene 
• 1533425-17-0 3,5-dichloro-4-cyclopropylaniline 
• 1533425-18-1 1,3-dichloro-2-cyclopropyl-5-isothiocyanatobenzene 

Relevant academic research and scientific papers

BORON-CONTAINING SMALL MOLECULES

This invention provides novel compounds, methods of using the compounds, and pharmaceutical formulations comprising the compounds.

1-Aryl-3,3-dialkyltriazenes: A convenient synthesis from dry arenediazonium o-benzenedisulfonimides - A high yield break down to the starting dry salts and efficient conversions to aryl iodides, bromides and chlorides

This research comprises three parts. The first part regards the synthesis of 1-aryl-3,3-dialkyltriazenes 3 by reaction of dry arenediazonium o-benzenedisulfonimides 1, also coming from weakly basic aromatic amines with dimethylamine or diethylamine in aqueous solution at 0-5 °C. Yields were usually greater than 90% and there was the possibility of recovering the o-benzenedisulfonimide (5), which could be reused to prepare the salts 1. In the second part it was demonstrated that there is the possibility of reconverting the triazenes 3 into the starting stable dry salts 1 by using 5 as acid. The reactions were carried out in glacial acetic acid at 50-55 °C and normally afforded salts 1 in yields of around 90-99%. The third part concerns the setting up of two procedures for the conversion of 3 to aryl iodides 9, bromides 10 and chlorides 11. Procedure A used the corresponding aqueous hydrogen halides in acetonitrile at r.t. or 60 °C, sometimes in the presence of aqueous HBF4, sometimes Cu powder (25 examples, yields 65%-88%). Procedure B usually used anhydrous methanesulfonic acid and tetraalkylammonium halides in anhydrous acetonitrile at temperatures varying from r.t. to 80 °C, sometimes in the presence of Cu (16 examples, yields 65-88%).

Pyridyl and pyridazinyl substituted thyronine compounds having selective thyromimetic activity

This invention relates to chemical compounds which have selective thyromimetic activity. A compound of this invention is 3,5-dibromo-3''-[6-oxo-3(1H)-pyridazinylmethyl]-thyronine.

Nucleophilic Displacement in Polyhalogenoaromatic Compounds. Part 11. Kinetics of Protiodeiodination of Iodoarenes in Dimethyl Sulphoxide-Methanol

The rates of methoxide-ion induced protiodeiodination of a number of polychloroiodobenzenes and their derivatives have been measured in dimethyl sulphoxide-methanol (9:1 v/v; 323.2 K).The true reagent under these conditions appears to be the dimethyl sulphoxide anion, and the rates of reaction in some cases appear to approach that expected of a diffusion controlled process.This corresponds to a major decrease in the efficacy of further activating substituents in the aromatic system, altough deactivating groups such as p-OMe still show large effects.Chlorine promotes protiodeiodination in the order of efficiency o-Cl > m-Cl > p-Cl; the trifluoromethyl group activates displacement in the order o-CF3 > p-CF3 > m-CF3, although with much less difference between isomeric sites. o-Nitro-groups promote protiodeiodination whereas the p-nitro-group encourages methoxydeiodination.No evidence of methoxydeiodination was found in attack of the polychloroiodobenzenes, although the rates of methoxydechlorination of the corresponding polychlorobenzenes suggest that in some cases this might occur.Evidence rejecting the possible SRN1 mechanism and supporting nucleophilic attack by a carbanionic species upon iodine is presented.