diethyl (2-((2-bromophenyl)(methyl)amino)-2-oxoethyl)phosphonate

Base Information

• Chemical Name: diethyl (2-((2-bromophenyl)(methyl)amino)-2-oxoethyl)phosphonate
• CAS No.: 1174751-04-2
• Molecular Formula: C₁₃H₁₉BrNO₄P
• Molecular Weight: 364.176
• Mol file: 1174751-04-2.mol

Synonyms:diethyl (2-((2-bromophenyl)(methyl)amino)-2-oxoethyl)phosphonate

Chemical Property of diethyl (2-((2-bromophenyl)(methyl)amino)-2-oxoethyl)phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of diethyl (2-((2-bromophenyl)(methyl)amino)-2-oxoethyl)phosphonate

There total 1 articles about diethyl (2-((2-bromophenyl)(methyl)amino)-2-oxoethyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethylphosphonoacetic acid (3095-95-2) + 2-bromoaniline (615-36-1) → diethyl (2-((2-bromophenyl)(methyl)amino)-2-oxoethyl)phosphonate (1174751-04-2)

Guidance literature:

DOI:10.1002/ejoc.200900294

Reference yield: 98.0%

diethyl (2-((2-bromophenyl)(methyl)amino)-2-oxoethyl)phosphonate (1174751-04-2) + benzaldehyde (100-52-7) → (E)-N-(2-bromophenyl)-N-methylcinnamamide (122101-00-2)

Guidance literature:

With caesium carbonate; In tetrahydrofuran; at 100 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

DOI:10.1016/j.tet.2010.03.018

Reference yield: 83.0%

diethyl (2-((2-bromophenyl)(methyl)amino)-2-oxoethyl)phosphonate (1174751-04-2) + benzaldehyde (100-52-7) → 3-benzylidene-1H-pyrrolo[2,3-b]pyridin-2(3H)-one (59181-30-5)

Guidance literature:

With palladium diacetate; caesium carbonate; triphenylphosphine; In tetrahydrofuran; at 100 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

DOI:10.1016/j.tet.2010.03.018

upstream raw materials:

diethylphosphonoacetic acid

2-bromoaniline

Downstream raw materials:

1,3-dimethyl-3-(1-phenylpentyl)-1,3-dihydro-2H-indol-2-one

(E)-1-methyl-3-benzylidene-2,3-dihydro-1H-indol-2-one

3-benzylidene-1-methyl-1,3-dihydroindol-2-one

C₁₆H₁₂N₂O₃