[{3-[2-(3-hydroxyprop-1-ynyl)phenyl]prop-2-ynyl}(toluene-4-sulfonyl)amino]acetic acid ethyl ester

Base Information

• Chemical Name: [{3-[2-(3-hydroxyprop-1-ynyl)phenyl]prop-2-ynyl}(toluene-4-sulfonyl)amino]acetic acid ethyl ester
• CAS No.: 1253043-76-3
• Molecular Formula: C₂₃H₂₃NO₅S
• Molecular Weight: 425.505

Synonyms:[{3-[2-(3-hydroxyprop-1-ynyl)phenyl]prop-2-ynyl}(toluene-4-sulfonyl)amino]acetic acid ethyl ester

Chemical Property of [{3-[2-(3-hydroxyprop-1-ynyl)phenyl]prop-2-ynyl}(toluene-4-sulfonyl)amino]acetic acid ethyl ester

Chemical Property:

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Technology Process of [{3-[2-(3-hydroxyprop-1-ynyl)phenyl]prop-2-ynyl}(toluene-4-sulfonyl)amino]acetic acid ethyl ester

There total 1 articles about [{3-[2-(3-hydroxyprop-1-ynyl)phenyl]prop-2-ynyl}(toluene-4-sulfonyl)amino]acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

[[3-(2-iodophenyl)prop-2-ynyl](toluene-4-sulfonyl)amino]acetic acid ethyl ester (1253043-75-2) + propargyl alcohol (107-19-7) → [{3-[2-(3-hydroxyprop-1-ynyl)phenyl]prop-2-ynyl}(toluene-4-sulfonyl)amino]acetic acid ethyl ester (1253043-76-3)

Guidance literature:

[[3-(2-iodophenyl)prop-2-ynyl](toluene-4-sulfonyl)amino]acetic acid ethyl ester; With copper(l) iodide; bis(triphenylphosphine)palladium(II) dichloride; triethylamine; In tetrahydrofuran; for 0.166667h; Inert atmosphere;

propargyl alcohol; With triethylamine; In tetrahydrofuran; at 40 ℃; for 1.5h; Inert atmosphere;

DOI:10.1021/ja106668d

Reference yield: 100.0%

[{3-[2-(3-hydroxyprop-1-ynyl)phenyl]prop-2-ynyl}(toluene-4-sulfonyl)amino]acetic acid ethyl ester (1253043-76-3) + methanesulfonyl chloride (124-63-0) → [{3-[2-(3-methanesulfonyloxyprop-1-ynyl)phenyl]prop-2-ynyl}(toluene-4-sulfonyl)amino]acetic acid ethyl ester (1253043-77-4)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 0.25h; Inert atmosphere;

DOI:10.1021/ja106668d

upstream raw materials:

[[3-(2-iodophenyl)prop-2-ynyl](toluene-4-sulfonyl)amino]acetic acid ethyl ester

propargyl alcohol

Downstream raw materials:

[{3-[2-(3-methanesulfonyloxyprop-1-ynyl)phenyl]prop-2-ynyl}(toluene-4-sulfonyl)amino]acetic acid ethyl ester

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