3′-O-benzyl-4,6;4′,6′-di-O-benzylidene-2′-O-tert-butyldimethylsilyl-2-O-palmitoyl-α,α-D-trehalose

Base Information

Chemical Name:3′-O-benzyl-4,6;4′,6′-di-O-benzylidene-2′-O-tert-butyldimethylsilyl-2-O-palmitoyl-α,α-D-trehalose
CAS No.:1450826-92-2
Molecular Formula:C₅₅H₈₀O₁₂Si
Molecular Weight:961.318
Hs Code.:

Synonyms:3′-O-benzyl-4,6;4′,6′-di-O-benzylidene-2′-O-tert-butyldimethylsilyl-2-O-palmitoyl-α,α-D-trehalose

Suppliers and Price of 3′-O-benzyl-4,6;4′,6′-di-O-benzylidene-2′-O-tert-butyldimethylsilyl-2-O-palmitoyl-α,α-D-trehalose

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3′-O-benzyl-4,6;4′,6′-di-O-benzylidene-2′-O-tert-butyldimethylsilyl-2-O-palmitoyl-α,α-D-trehalose

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3′-O-benzyl-4,6;4′,6′-di-O-benzylidene-2′-O-tert-butyldimethylsilyl-2-O-palmitoyl-α,α-D-trehalose

There total 7 articles about 3′-O-benzyl-4,6;4′,6′-di-O-benzylidene-2′-O-tert-butyldimethylsilyl-2-O-palmitoyl-α,α-D-trehalose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1448242-53-2
3′-O-benzyl-4,6;4′,6′-di-O-benzylidene-2′-O-tert-butyldimethylsilyl-α,α-D-trehalose

: 57-10-3
1-hexadecylcarboxylic acid

: 1450826-92-2
3′-O-benzyl-4,6;4′,6′-di-O-benzylidene-2′-O-tert-butyldimethylsilyl-2-O-palmitoyl-α,α-D-trehalose

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 4h; regioselective reaction;
DOI:10.1002/cbic.201300482

Reference yield:

: 100-52-7
benzaldehyde

: 1450826-92-2
3′-O-benzyl-4,6;4′,6′-di-O-benzylidene-2′-O-tert-butyldimethylsilyl-2-O-palmitoyl-α,α-D-trehalose

Guidance literature:: Multi-step reaction with 4 steps

1: iron(III) chloride hexahydrate; triethylsilane / dichloromethane; acetonitrile / 3 h / 20 °C / Cooling with ice; Inert atmosphere

2: 2,6-dimethylpyridine / dichloromethane / 3 h / -78 °C / Inert atmosphere

3: ammonium formate; palladium 10% on activated carbon / methanol / 0.75 h / Reflux; Inert atmosphere

4: dicyclohexyl-carbodiimide; dmap / dichloromethane / 5 h / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; triethylsilane; dmap; iron(III) chloride hexahydrate; palladium 10% on activated carbon; ammonium formate; dicyclohexyl-carbodiimide; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/jo4012255

Reference yield:

: 42390-78-3
2,3,4,6,2',3',4',6'-octa-O-trimethylsilyl-α,α-D-trehalose

: 1450826-92-2
3′-O-benzyl-4,6;4′,6′-di-O-benzylidene-2′-O-tert-butyldimethylsilyl-2-O-palmitoyl-α,α-D-trehalose

Guidance literature:: Multi-step reaction with 4 steps

1: iron(III) chloride hexahydrate; triethylsilane / dichloromethane; acetonitrile / 3 h / 20 °C / Cooling with ice; Inert atmosphere

2: 2,6-dimethylpyridine / dichloromethane / 3 h / -78 °C / Inert atmosphere

3: ammonium formate; palladium 10% on activated carbon / methanol / 0.75 h / Reflux; Inert atmosphere

4: dicyclohexyl-carbodiimide; dmap / dichloromethane / 5 h / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; triethylsilane; dmap; iron(III) chloride hexahydrate; palladium 10% on activated carbon; ammonium formate; dicyclohexyl-carbodiimide; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/jo4012255