Methanesulfonic acid 1-[2,6-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-4-oxo-3-phenylacetylamino-azetidin-2-ylmethyl ester

Base Information

Chemical Name:Methanesulfonic acid 1-[2,6-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-4-oxo-3-phenylacetylamino-azetidin-2-ylmethyl ester
CAS No.:69825-19-0
Molecular Formula:C₃₁H₄₈N₂O₇SSi₂
Molecular Weight:648.968
Hs Code.:

Synonyms:Methanesulfonic acid 1-[2,6-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-4-oxo-3-phenylacetylamino-azetidin-2-ylmethyl ester

Suppliers and Price of Methanesulfonic acid 1-[2,6-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-4-oxo-3-phenylacetylamino-azetidin-2-ylmethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Methanesulfonic acid 1-[2,6-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-4-oxo-3-phenylacetylamino-azetidin-2-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid 1-[2,6-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-4-oxo-3-phenylacetylamino-azetidin-2-ylmethyl ester

There total 7 articles about Methanesulfonic acid 1-[2,6-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-4-oxo-3-phenylacetylamino-azetidin-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: Methanesulfonic acid 3-azido-1-[2,6-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-4-oxo-azetidin-2-ylmethyl ester

: 103-80-0
phenylacetyl chloride

: 69825-19-0
Methanesulfonic acid 1-[2,6-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-4-oxo-3-phenylacetylamino-azetidin-2-ylmethyl ester

Guidance literature:: With triethylamine; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1139/v81-432

Reference yield:

: 601-89-8
2-nitroresorcinol

: 69825-19-0
Methanesulfonic acid 1-[2,6-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-4-oxo-3-phenylacetylamino-azetidin-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogen / PtO₂ / ethanol / 2068.6 Torr

2: imidazole / dimethylformamide / Ambient temperature

3: p-TsOH / benzene / Heating

4: CH₂Cl₂ / 1 h / -20 °C

5: 1) ozone; 2) NaBH₄ / 1) EtOH, CH₂Cl₂, -78 deg C; 2) -40 deg C --> room temp.

6: 95 percent / Et₃N / CH₂Cl₂ / 1) -78 deg C, O_.5 h; 2) room temp., 1 h

7: 79 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

With 1H-imidazole; sodium tetrahydroborate; hydrogen; toluene-4-sulfonic acid; ozone; triethylamine; platinum(IV) oxide; In ethanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1139/v81-432

Reference yield:

: 69589-23-7
di-tert-butyldimethylsilyl-2-aminoresorcinol

: 69825-19-0
Methanesulfonic acid 1-[2,6-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-4-oxo-3-phenylacetylamino-azetidin-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: p-TsOH / benzene / Heating

2: CH₂Cl₂ / 1 h / -20 °C

3: 1) ozone; 2) NaBH₄ / 1) EtOH, CH₂Cl₂, -78 deg C; 2) -40 deg C --> room temp.

4: 95 percent / Et₃N / CH₂Cl₂ / 1) -78 deg C, O_.5 h; 2) room temp., 1 h

5: 79 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

With sodium tetrahydroborate; toluene-4-sulfonic acid; ozone; triethylamine; In dichloromethane; benzene;
DOI:10.1139/v81-432