tert-butyl 2-(methylthio)-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-7-ylcarbamate

Base Information

Chemical Name:tert-butyl 2-(methylthio)-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-7-ylcarbamate
CAS No.:1062135-91-4
Molecular Formula:C₂₂H₂₇N₇O₄S
Molecular Weight:485.567
Hs Code.:

Synonyms:tert-butyl 2-(methylthio)-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-7-ylcarbamate

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Chemical Property of tert-butyl 2-(methylthio)-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-7-ylcarbamate

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Technology Process of tert-butyl 2-(methylthio)-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-7-ylcarbamate

There total 3 articles about tert-butyl 2-(methylthio)-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-7-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.6%

: 1062135-89-0
tert-butyl 2,4-bis(methylthio)imidazo[1,2-f][1,2,4]triazin-7-ylcarbamate

: 51207-86-4
(4-amino-phenyl)-morpholin-4-yl-methanone

: 1062135-91-4
tert-butyl 2-(methylthio)-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-7-ylcarbamate

Guidance literature:: tert-butyl 2,4-bis(methylthio)imidazo[1,2-f][1,2,4]triazin-7-ylcarbamate; (4-amino-phenyl)-morpholin-4-yl-methanone; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 1.08333h;

With hydrogenchloride; In tetrahydrofuran; water; pH=9 - 10;

Reference yield:

: 1062135-87-8
7-bromo-2,4-bis(methylthio)imidazo[2,1-f][1,2,4]triazine

: 1062135-91-4
tert-butyl 2-(methylthio)-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-7-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

1.2: 1.33 h / -78 - 20 °C

1.3: pH 5

2.1: diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine / 3 h / Heating / reflux

3.1: potassium tert-butylate / tetrahydrofuran / 1.08 h / 20 °C

3.2: pH 9 - 10

With n-butyllithium; diphenyl phosphoryl azide; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

Reference yield:

: 1062135-88-9
2,4-bis(methylthio)imidazo[1,2-f][1,2,4]triazine-7-carboxylic acid

: 1062135-91-4
tert-butyl 2-(methylthio)-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-7-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine / 3 h / Heating / reflux

2.1: potassium tert-butylate / tetrahydrofuran / 1.08 h / 20 °C

2.2: pH 9 - 10

With diphenyl phosphoryl azide; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;