tert-butyl 2-(methylsulfonyl)-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-7-ylcarbamate

Base Information

Chemical Name:tert-butyl 2-(methylsulfonyl)-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-7-ylcarbamate
CAS No.:1062135-92-5
Molecular Formula:C₂₂H₂₇N₇O₆S
Molecular Weight:517.566
Hs Code.:

Synonyms:tert-butyl 2-(methylsulfonyl)-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-7-ylcarbamate

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Chemical Property of tert-butyl 2-(methylsulfonyl)-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-7-ylcarbamate

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Technology Process of tert-butyl 2-(methylsulfonyl)-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-7-ylcarbamate

There total 6 articles about tert-butyl 2-(methylsulfonyl)-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-7-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1062135-91-4
tert-butyl 2-(methylthio)-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-7-ylcarbamate

: 1062135-92-5
tert-butyl 2-(methylsulfonyl)-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-7-ylcarbamate

Guidance literature:: tert-butyl 2-(methylthio)-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-7-ylcarbamate; With 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; at 20 ℃; for 3h;

With sodium thiosulfate; In tetrahydrofuran; water; ethyl acetate;

With sodium carbonate; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

: 1062135-87-8
7-bromo-2,4-bis(methylthio)imidazo[2,1-f][1,2,4]triazine

: 1062135-92-5
tert-butyl 2-(methylsulfonyl)-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-7-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

1.2: 1.33 h / -78 - 20 °C

1.3: pH 5

2.1: diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine / 3 h / Heating / reflux

3.1: potassium tert-butylate / tetrahydrofuran / 1.08 h / 20 °C

3.2: pH 9 - 10

4.1: 3-chloro-benzenecarboperoxoic acid / tetrahydrofuran / 3 h / 20 °C

With n-butyllithium; diphenyl phosphoryl azide; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran;

Reference yield:

: 1062135-88-9
2,4-bis(methylthio)imidazo[1,2-f][1,2,4]triazine-7-carboxylic acid

: 1062135-92-5
tert-butyl 2-(methylsulfonyl)-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-7-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine / 3 h / Heating / reflux

2.1: potassium tert-butylate / tetrahydrofuran / 1.08 h / 20 °C

2.2: pH 9 - 10

3.1: 3-chloro-benzenecarboperoxoic acid / tetrahydrofuran / 3 h / 20 °C

With diphenyl phosphoryl azide; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran;