methyl 11-(2-aminoethyl)thio-6,11-dihydrodibenz[b,e]oxepin-2-acetate

Base Information

• Chemical Name: methyl 11-(2-aminoethyl)thio-6,11-dihydrodibenz[b,e]oxepin-2-acetate
• CAS No.: 123227-54-3
• Molecular Formula: C₁₉H₂₁NO₃S
• Molecular Weight: 343.447
• Mol file: 123227-54-3.mol

Synonyms:methyl 11-(2-aminoethyl)thio-6,11-dihydrodibenz[b,e]oxepin-2-acetate

Chemical Property of methyl 11-(2-aminoethyl)thio-6,11-dihydrodibenz[b,e]oxepin-2-acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 11-(2-aminoethyl)thio-6,11-dihydrodibenz[b,e]oxepin-2-acetate

There total 1 articles about methyl 11-(2-aminoethyl)thio-6,11-dihydrodibenz[b,e]oxepin-2-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetate (55689-64-0) → methyl 11-(2-aminoethyl)thio-6,11-dihydrodibenz[b,e]oxepin-2-acetate (123227-54-3)

Guidance literature:

Multi-step reaction with 3 steps

1: NaBH₄ / methanol

2: p-toluenesulfonic acid

3: BF₃*Et₂O / CH₂Cl₂ / 3 h / Ambient temperature

With sodium tetrahydroborate; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; In methanol; dichloromethane;

DOI:10.1021/jm00096a016

Reference yield:

methyl 11-(2-aminoethyl)thio-6,11-dihydrodibenz[b,e]oxepin-2-acetate (123227-54-3) → sodium 11-[2-[(phenylsulfonyl)amino]ethyl]thio-6,11-dihydrodibenz[b,e]oxepin-2-acetate (123226-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

2: 10 N aq. NaOH / H₂O; methanol / 2.5 h / Heating

With sodium hydroxide; triethylamine; In methanol; dichloromethane; water;

DOI:10.1021/jm00096a016

Reference yield:

methyl 11-(2-aminoethyl)thio-6,11-dihydrodibenz[b,e]oxepin-2-acetate (123227-54-3) + benzenesulfonyl chloride (98-09-9) → [11-(2-Benzenesulfonylamino-ethylsulfanyl)-6,11-dihydro-dibenzo[b,e]oxepin-2-yl]-acetic acid methyl ester (123226-65-3)

Guidance literature:

With triethylamine; In dichloromethane; for 3h; Ambient temperature;

DOI:10.1021/jm00096a016

upstream raw materials:

methyl 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetate

Downstream raw materials:

[11-(2-Benzenesulfonylamino-ethylsulfanyl)-6,11-dihydro-dibenzo[b,e]oxepin-2-yl]-acetic acid methyl ester

sodium 11-[2-[(phenylsulfonyl)amino]ethyl]thio-6,11-dihydrodibenz[b,e]oxepin-2-acetate