N-(2-((1S,2S)-2-(1-(5-chloro-pyrimidin-2-yl)piperidin-4-yl)-cyclopropyl)ethyl)-4-(1H-tetrazol-1-yl)-aniline

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Chemical Name:N-(2-((1S,2S)-2-(1-(5-chloro-pyrimidin-2-yl)piperidin-4-yl)-cyclopropyl)ethyl)-4-(1H-tetrazol-1-yl)-aniline
CAS No.:1266336-68-8
Molecular Formula:C₂₁H₂₅ClN₈
Molecular Weight:424.936
Hs Code.:

Synonyms:N-(2-((1S,2S)-2-(1-(5-chloro-pyrimidin-2-yl)piperidin-4-yl)-cyclopropyl)ethyl)-4-(1H-tetrazol-1-yl)-aniline

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Chemical Property of N-(2-((1S,2S)-2-(1-(5-chloro-pyrimidin-2-yl)piperidin-4-yl)-cyclopropyl)ethyl)-4-(1H-tetrazol-1-yl)-aniline

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Technology Process of N-(2-((1S,2S)-2-(1-(5-chloro-pyrimidin-2-yl)piperidin-4-yl)-cyclopropyl)ethyl)-4-(1H-tetrazol-1-yl)-aniline

There total 9 articles about N-(2-((1S,2S)-2-(1-(5-chloro-pyrimidin-2-yl)piperidin-4-yl)-cyclopropyl)ethyl)-4-(1H-tetrazol-1-yl)-aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14213-13-9
4-tetrazol-1-yl-phenylamine

: 1266335-55-0
2-{(1S,2R)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethyl 4-methylbenzenesulfonate

: 1266336-68-8
N-(2-((1S,2S)-2-(1-(5-chloro-pyrimidin-2-yl)piperidin-4-yl)-cyclopropyl)ethyl)-4-(1H-tetrazol-1-yl)-aniline

Guidance literature:: With potassium iodide; In acetonitrile; at 170 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 287192-97-6
4-ethynyl-piperidine-1-carboxylic acid tert-butyl ester

: 1266336-68-8
N-(2-((1S,2S)-2-(1-(5-chloro-pyrimidin-2-yl)piperidin-4-yl)-cyclopropyl)ethyl)-4-(1H-tetrazol-1-yl)-aniline

Guidance literature:: Multi-step reaction with 10 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / -78 °C

1.2: -78 °C

2.1: hydrogen; quinoline / Lindlar catalyst / ethyl acetate / 0.67 h

3.1: diethylzinc / dichloromethane; diethyl ether / -20 °C / Inert atmosphere

3.2: 0.17 h / -20 °C / Inert atmosphere

3.3: 24 h / -20 - 0 °C / Inert atmosphere

4.1: hydrogen / 20 % Pd(OH)2/C / ethyl acetate; ethanol / 0.5 h / 2585.81 Torr

5.1: sodium periodate / dichloromethane; water / 0 °C

6.1: ethanol; sodium tetrahydroborate / 0.5 h / 20 °C

7.1: trifluoroacetic acid / dichloromethane / 0 °C

8.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

9.1: triethylamine / dmap / dichloromethane / 1.5 h / Inert atmosphere

10.1: potassium iodide / acetonitrile / 0.5 h / 170 °C / Microwave irradiation

With quinoline; sodium tetrahydroborate; sodium periodate; n-butyllithium; ethanol; hydrogen; diethylzinc; caesium carbonate; triethylamine; trifluoroacetic acid; potassium iodide; dmap; 20 % Pd(OH)2/C; In tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 3.1: Charette cyclopropanation;

Reference yield:

: 1192063-83-4
tert-butyl 4-{(1R,2S)-2-[(2R)-3-(benzyloxy)-2-hydroxy-propyl]cyclopropyl}piperidine-1-carboxylate

: 1266336-68-8
N-(2-((1S,2S)-2-(1-(5-chloro-pyrimidin-2-yl)piperidin-4-yl)-cyclopropyl)ethyl)-4-(1H-tetrazol-1-yl)-aniline

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogen / 20 % Pd(OH)2/C / ethyl acetate; ethanol / 0.5 h / 2585.81 Torr

2: sodium periodate / dichloromethane; water / 0 °C

3: ethanol; sodium tetrahydroborate / 0.5 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 0 °C

5: caesium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

6: triethylamine / dmap / dichloromethane / 1.5 h / Inert atmosphere

7: potassium iodide / acetonitrile / 0.5 h / 170 °C / Microwave irradiation

With sodium tetrahydroborate; sodium periodate; ethanol; hydrogen; caesium carbonate; triethylamine; trifluoroacetic acid; potassium iodide; dmap; 20 % Pd(OH)2/C; In ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;