2-(tert-butyldiphenylsilanyloxymethyl)-5-hydroxy pyrrolidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:2-(tert-butyldiphenylsilanyloxymethyl)-5-hydroxy pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:157979-33-4
Molecular Formula:C₂₆H₃₇NO₄Si
Molecular Weight:455.67
Hs Code.:

Synonyms:2-(tert-butyldiphenylsilanyloxymethyl)-5-hydroxy pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 2-(tert-butyldiphenylsilanyloxymethyl)-5-hydroxy pyrrolidine-1-carboxylic acid tert-butyl ester

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Technology Process of 2-(tert-butyldiphenylsilanyloxymethyl)-5-hydroxy pyrrolidine-1-carboxylic acid tert-butyl ester

There total 4 articles about 2-(tert-butyldiphenylsilanyloxymethyl)-5-hydroxy pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.7%

: 2-(tert-butyldiphenylsilanyloxymethyl)-5-oxo pyrrolidine-1-carboxylic acid tert-butyl ester

: 157979-33-4
2-(tert-butyldiphenylsilanyloxymethyl)-5-hydroxy pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: 2-(tert-butyldiphenylsilanyloxymethyl)-5-oxo pyrrolidine-1-carboxylic acid tert-butyl ester; With lithium triethylborohydride; In tetrahydrofuran; at -78 ℃; for 1h;

With sodium hydrogencarbonate; In tetrahydrofuran;

With dihydrogen peroxide; In tetrahydrofuran; water; at 0 ℃; for 0.333333h;

Reference yield:

: 62400-75-3
pyroglutamol

: 157979-33-4
2-(tert-butyldiphenylsilanyloxymethyl)-5-hydroxy pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; 1H-imidazole / dichloromethane / 20 °C / Cooling with ice

2.1: dmap / acetonitrile / 16 h / 20 °C

3.1: lithium triethylborohydride / tetrahydrofuran / 1 h / -78 °C

3.3: 0.33 h / 0 °C

With 1H-imidazole; dmap; lithium triethylborohydride; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 157979-33-4
2-(tert-butyldiphenylsilanyloxymethyl)-5-hydroxy pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; 1H-imidazole / dichloromethane / 20 °C / Cooling with ice

2.1: dmap / acetonitrile / 16 h / 20 °C

3.1: lithium triethylborohydride / tetrahydrofuran / 1 h / -78 °C

3.3: 0.33 h / 0 °C

With 1H-imidazole; dmap; lithium triethylborohydride; In tetrahydrofuran; dichloromethane; acetonitrile;