2-(tert-butyldiphenylsilanyloxymethyl)-5-methoxypyrrolidine-1-carboxylic acid tertbutyl ester

Base Information

Chemical Name:2-(tert-butyldiphenylsilanyloxymethyl)-5-methoxypyrrolidine-1-carboxylic acid tertbutyl ester
CAS No.:157979-35-6
Molecular Formula:C₂₇H₃₉NO₄Si
Molecular Weight:469.696
Hs Code.:

Synonyms:2-(tert-butyldiphenylsilanyloxymethyl)-5-methoxypyrrolidine-1-carboxylic acid tertbutyl ester

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Chemical Property of 2-(tert-butyldiphenylsilanyloxymethyl)-5-methoxypyrrolidine-1-carboxylic acid tertbutyl ester

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Technology Process of 2-(tert-butyldiphenylsilanyloxymethyl)-5-methoxypyrrolidine-1-carboxylic acid tertbutyl ester

There total 5 articles about 2-(tert-butyldiphenylsilanyloxymethyl)-5-methoxypyrrolidine-1-carboxylic acid tertbutyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.7%

: 67-56-1
methanol

: 157979-33-4
2-(tert-butyldiphenylsilanyloxymethyl)-5-hydroxy pyrrolidine-1-carboxylic acid tert-butyl ester

: 157979-35-6
2-(tert-butyldiphenylsilanyloxymethyl)-5-methoxypyrrolidine-1-carboxylic acid tertbutyl ester

Guidance literature:: methanol; 2-(tert-butyldiphenylsilanyloxymethyl)-5-hydroxy pyrrolidine-1-carboxylic acid tert-butyl ester; With pyridinium p-toluenesulfonate; at 20 ℃; Cooling with ice;

With triethylamine;

Reference yield:

: 2-(tert-butyldiphenylsilanyloxymethyl)-5-oxo pyrrolidine-1-carboxylic acid tert-butyl ester

: 157979-35-6
2-(tert-butyldiphenylsilanyloxymethyl)-5-methoxypyrrolidine-1-carboxylic acid tertbutyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium triethylborohydride / tetrahydrofuran / 1 h / -78 °C

1.3: 0.33 h / 0 °C

2.1: pyridinium p-toluenesulfonate / 20 °C / Cooling with ice

With pyridinium p-toluenesulfonate; lithium triethylborohydride; In tetrahydrofuran;

Reference yield:

: 62400-75-3
pyroglutamol

: 157979-35-6
2-(tert-butyldiphenylsilanyloxymethyl)-5-methoxypyrrolidine-1-carboxylic acid tertbutyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; 1H-imidazole / dichloromethane / 20 °C / Cooling with ice

2.1: dmap / acetonitrile / 16 h / 20 °C

3.1: lithium triethylborohydride / tetrahydrofuran / 1 h / -78 °C

3.3: 0.33 h / 0 °C

4.1: pyridinium p-toluenesulfonate / 20 °C / Cooling with ice

With 1H-imidazole; dmap; pyridinium p-toluenesulfonate; lithium triethylborohydride; In tetrahydrofuran; dichloromethane; acetonitrile;