t-butyl 3-[N-(benzyloxycarbonyl)-N-(methyl)aminomethyl]-2-azabicyclo[3.1.0]hexane-2-carboxylate

Base Information

Chemical Name:t-butyl 3-[N-(benzyloxycarbonyl)-N-(methyl)aminomethyl]-2-azabicyclo[3.1.0]hexane-2-carboxylate
CAS No.:1313816-85-1
Molecular Formula:C₂₀H₂₈N₂O₄
Molecular Weight:360.453
Hs Code.:

Synonyms:t-butyl 3-[N-(benzyloxycarbonyl)-N-(methyl)aminomethyl]-2-azabicyclo[3.1.0]hexane-2-carboxylate

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Chemical Property of t-butyl 3-[N-(benzyloxycarbonyl)-N-(methyl)aminomethyl]-2-azabicyclo[3.1.0]hexane-2-carboxylate

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Technology Process of t-butyl 3-[N-(benzyloxycarbonyl)-N-(methyl)aminomethyl]-2-azabicyclo[3.1.0]hexane-2-carboxylate

There total 8 articles about t-butyl 3-[N-(benzyloxycarbonyl)-N-(methyl)aminomethyl]-2-azabicyclo[3.1.0]hexane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1313816-84-0
3-methylaminomethyl-2-azabicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester

: 501-53-1,94274-21-2
benzyl chloroformate

: 1313816-85-1
t-butyl 3-[N-(benzyloxycarbonyl)-N-(methyl)aminomethyl]-2-azabicyclo[3.1.0]hexane-2-carboxylate

Guidance literature:: With potassium carbonate; In tetrahydrofuran; toluene; at 20 ℃; for 16h; Cooling with ice;

Reference yield:

: 157979-33-4
2-(tert-butyldiphenylsilanyloxymethyl)-5-hydroxy pyrrolidine-1-carboxylic acid tert-butyl ester

: 1313816-85-1
t-butyl 3-[N-(benzyloxycarbonyl)-N-(methyl)aminomethyl]-2-azabicyclo[3.1.0]hexane-2-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: pyridinium p-toluenesulfonate / 2 h / 20 °C / Cooling with ice

2: ammonium chloride / 1 h / 150 °C / 37.5 Torr

3: diethylzinc / dichloromethane / 3.75 h / 20 °C / Cooling with ice

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 12.17 h / 20 °C / Cooling with ice

5: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice

6: N,N-dimethyl-formamide; water / 24 h

7: potassium carbonate / toluene; tetrahydrofuran / 16 h / 20 °C / Cooling with ice

With tetrabutyl ammonium fluoride; diethylzinc; pyridinium p-toluenesulfonate; potassium carbonate; ammonium chloride; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 157979-35-6
2-(tert-butyldiphenylsilanyloxymethyl)-5-methoxypyrrolidine-1-carboxylic acid tertbutyl ester

: 1313816-85-1
t-butyl 3-[N-(benzyloxycarbonyl)-N-(methyl)aminomethyl]-2-azabicyclo[3.1.0]hexane-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: ammonium chloride / 1 h / 150 °C / 37.5 Torr

2: diethylzinc / dichloromethane / 3.75 h / 20 °C / Cooling with ice

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 12.17 h / 20 °C / Cooling with ice

4: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice

5: N,N-dimethyl-formamide; water / 24 h

6: potassium carbonate / toluene; tetrahydrofuran / 16 h / 20 °C / Cooling with ice

With tetrabutyl ammonium fluoride; diethylzinc; potassium carbonate; ammonium chloride; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;