Febuxostat Impurity 7

Base Information

• Chemical Name: Febuxostat Impurity 7
• CAS No.: 1350352-70-3
• Molecular Formula: C₁₆H₁₈N₂O₄S
• Molecular Weight: 334.396
• Mol file: 1350352-70-3.mol

Synonyms:2-[3-((hydroxyimino)methyl)-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid

Chemical Property of Febuxostat Impurity 7

Chemical Property:

• Melting Point: >215°C (dec.)
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly)

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

3-Descyano-3-((hydroxyimino)methyl)Febuxostat ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 3-Descyano-3-((hydroxyimino)methyl) Febuxostat is an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor that is used for treating hyperuricemia and chronic gout.

Technology Process of Febuxostat Impurity 7

There total 3 articles about Febuxostat Impurity 7 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-[3-((hydroxyimino)methyl)-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylate (1271738-74-9) → 2-[3-((hydroxyimino)methyl)-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid (1350352-70-3)

Guidance literature:

ethyl 2-[3-((hydroxyimino)methyl)-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylate; With water; sodium hydroxide; In methanol; at 75 ℃; for 0.5h;

With hydrogenchloride; In methanol; water; at 25 ℃; for 5h; pH=2 - 3;

Reference yield:

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester (161798-03-4) → 2-[3-((hydroxyimino)methyl)-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid (1350352-70-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydroxylamine hydrochloride / methanol / 65 °C

2.1: sodium hydroxide; water / methanol / 0.5 h / 75 °C

2.2: hydrose / 5 h / 25 °C / pH 2 - 3

With hydroxylamine hydrochloride; water; sodium hydroxide; In methanol;

Reference yield:

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate (161798-01-2) → 2-[3-((hydroxyimino)methyl)-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid (1350352-70-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 0.5 h / 70 - 75 °C

1.2: 5 h

2.1: hydroxylamine hydrochloride / methanol / 65 °C

3.1: sodium hydroxide; water / methanol / 0.5 h / 75 °C

3.2: hydrose / 5 h / 25 °C / pH 2 - 3

With hydroxylamine hydrochloride; water; potassium carbonate; potassium iodide; sodium hydroxide; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

2-(3-formyl-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester

ethyl 2-[3-((hydroxyimino)methyl)-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylate

ethyl 2‐(3‐formyl‐4‐hydroxyphenyl)‐4‐methylthiazole‐5‐carboxylate

Downstream raw materials:

2-[3-((hydroxyimino)methyl)-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid methylamine

2-[3-((hydroxyimino)methyl)-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid n-butylamine

febuxostat

2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid methylamine

Refernces