2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid methylamine

Base Information

Chemical Name:2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid methylamine
CAS No.:1350352-71-4
Molecular Formula:CH₅N*C₁₆H₁₆N₂O₃S
Molecular Weight:347.438
Hs Code.:

Synonyms:2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid methylamine

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Chemical Property of 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid methylamine

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Technology Process of 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid methylamine

There total 13 articles about 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 74-89-5
methylamine

: 144060-53-7
febuxostat

: 1350352-71-4
2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid methylamine

Guidance literature:: In tetrahydrofuran; ethanol; at 20 ℃; Product distribution / selectivity;

Reference yield:

: 34133-58-9
4-hydroxy-isophthalonitrile

: 1350352-71-4
2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid methylamine

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate; potassium iodide / dimethyl sulfoxide / 16 h / 70 - 75 °C

2: hydrogenchloride; thioacetamide / isopropyl alcohol / 14 h / 40 - 45 °C

3: ethyl acetate; N,N-dimethyl-formamide / 22 h / 80 - 85 °C

4: sodium hydroxide; ethanol / tetrahydrofuran / 1 h / 60 °C

5: ethyl acetate; cyclohexane; methanol / 3 h

With hydrogenchloride; ethanol; potassium carbonate; thioacetamide; potassium iodide; sodium hydroxide; In tetrahydrofuran; methanol; cyclohexane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 615-58-7
2,4-dibromophenol

: 1350352-71-4
2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid methylamine

Guidance literature:: Multi-step reaction with 6 steps

1: palladium diacetate / dimethyl sulfoxide / 4 h / 40 - 45 °C

2: potassium carbonate; potassium iodide / dimethyl sulfoxide / 16 h / 70 - 75 °C

3: hydrogenchloride; thioacetamide / isopropyl alcohol / 14 h / 40 - 45 °C

4: ethyl acetate; N,N-dimethyl-formamide / 22 h / 80 - 85 °C

5: sodium hydroxide; ethanol / tetrahydrofuran / 1 h / 60 °C

6: ethyl acetate; cyclohexane; methanol / 3 h

With hydrogenchloride; ethanol; potassium carbonate; thioacetamide; potassium iodide; sodium hydroxide; palladium diacetate; In tetrahydrofuran; methanol; cyclohexane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;