(2S,5S)-1-(4-methoxybenzyl)-2,5-dimethyl-4-(2-nitrophenylsulfonyl)piperazine

Base Information

Chemical Name:(2S,5S)-1-(4-methoxybenzyl)-2,5-dimethyl-4-(2-nitrophenylsulfonyl)piperazine
CAS No.:1589599-08-5
Molecular Formula:C₂₀H₂₅N₃O₅S
Molecular Weight:419.502
Hs Code.:

Synonyms:(2S,5S)-1-(4-methoxybenzyl)-2,5-dimethyl-4-(2-nitrophenylsulfonyl)piperazine

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Chemical Property of (2S,5S)-1-(4-methoxybenzyl)-2,5-dimethyl-4-(2-nitrophenylsulfonyl)piperazine

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Technology Process of (2S,5S)-1-(4-methoxybenzyl)-2,5-dimethyl-4-(2-nitrophenylsulfonyl)piperazine

There total 7 articles about (2S,5S)-1-(4-methoxybenzyl)-2,5-dimethyl-4-(2-nitrophenylsulfonyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1589599-22-3
(2R)-2-hydroxy-N-[(2'S)-1'-{[(4-methoxyphenyl)methyl]amino}propan-2-yl]-S-(2'-nitrophenyl)propane-1-sulfonamide

: 1589599-08-5
(2S,5S)-1-(4-methoxybenzyl)-2,5-dimethyl-4-(2-nitrophenylsulfonyl)piperazine

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃; for 16h;
DOI:10.1039/c3ob42512f

Reference yield:

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 1589599-08-5
(2S,5S)-1-(4-methoxybenzyl)-2,5-dimethyl-4-(2-nitrophenylsulfonyl)piperazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / dichloromethane; water / 24 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

2.2: 24 h / 20 °C

3.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 16 h / 0 - 20 °C

With sodium hydride; sodium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/c3ob42512f

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1589599-08-5
(2S,5S)-1-(4-methoxybenzyl)-2,5-dimethyl-4-(2-nitrophenylsulfonyl)piperazine

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol / 50 °C / Molecular sieve

2.1: sodium tetrahydroborate / 0 - 20 °C

3.1: thionyl chloride; triethylamine; 1H-imidazole / dichloromethane / 3 h / -60 °C

4.1: ruthenium(III) chloride trihydrate; sodium periodate / acetonitrile; water / 0 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

5.2: 24 h / 20 °C

6.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 16 h / 0 - 20 °C

With 1H-imidazole; sodium tetrahydroborate; sodium periodate; thionyl chloride; ruthenium(III) chloride trihydrate; sodium hydride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c3ob42512f