2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid

Base Information

• Chemical Name: 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid
• CAS No.: 929345-60-8
• Molecular Formula: C12H12N2O2
• Molecular Weight: 216.23588
• Hs Code.: 2933990090
• Mol file: 929345-60-8.mol

Synonyms:2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid

Chemical Property of 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid

Chemical Property:

• PSA: 65.12000
• Density: 1.375
• LogP: 1.84060

Purity/Quality:

99% ^*data from raw suppliers

2,3,4,5-Tetrahydro-1H-pyrido[4,3-B]indole-8-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid

There total 2 articles about 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-piperidone hydrochloride (41979-39-9) + 4-hydrazinobenzoic acid hydrochloride (24589-77-3,52455-33-1) → 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid (929345-60-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 17 ℃; Heating / reflux;

Reference yield:

4-piperidinone monohydrate (73390-11-1) + 4-Hydrazinobenzoic acid (619-67-0) → 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid (929345-60-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; Reflux;

DOI:10.1016/j.bmcl.2011.12.124

Reference yield: 100.0%

methanol (67-56-1) + 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid (929345-60-8) → methyl 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylate (1015082-04-8)

Guidance literature:

With acetyl chloride; for 3.5h; Heating / reflux;

upstream raw materials:

4-piperidone hydrochloride

4-hydrazinobenzoic acid hydrochloride

4-piperidinone monohydrate

4-Hydrazinobenzoic acid

Downstream raw materials:

methyl 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylate

tert-butyl 8-[(4-methylpiperidin-1-yl)carbonyl]-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate

C₂₈H₃₃N₃O

tert-butyl 5-(4-ethoxybenzyl)-8-[(4-methylpiperidin-1-yl)carbonyl]-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate