tert-butyl 4-(4-((4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

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Chemical Name:tert-butyl 4-(4-((4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate
CAS No.:1566543-76-7
Molecular Formula:C₃₃H₃₈F₃N₅O₃
Molecular Weight:609.692
Hs Code.:

Synonyms:tert-butyl 4-(4-((4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-((4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(4-((4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

There total 10 articles about tert-butyl 4-(4-((4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1566543-75-6
1-(2-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxylic acid

: 1566543-76-7
tert-butyl 4-(4-((4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

Guidance literature:: 1-(2-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; for 0.166667h; Inert atmosphere;

With ammonium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; at 40 ℃; for 72h;

Reference yield:

: 170011-57-1
tert-butyl 4-(4-aminophenyl)piperidin-1-carboxylate

: 1566543-76-7
tert-butyl 4-(4-((4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: zinc(II) chloride / butan-1-ol; cis-1,2-Dichloroethylene; diethyl ether / 0.17 h / 20 °C

1.2: 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; Tetra(tert-butyl)phosphonium-tetrafluoroborat; copper(l) iodide / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

2.2: 0.33 h / 120 °C / Microwave irradiation

3.1: hydrogen; triethylamine / N,N-dimethyl-formamide / 16 h

4.1: lithium hydroxide / tetrahydrofuran; water; methanol / 3.5 h / 20 - 40 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

5.2: 72 h / 40 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; Tetra(tert-butyl)phosphonium-tetrafluoroborat; zinc(II) chloride; lithium hydroxide; In tetrahydrofuran; cis-1,2-Dichloroethylene; methanol; diethyl ether; water; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 1566543-72-3
tert-butyl 4-(4-((4-((2-(1-(methoxycarbonyl)cyclopropyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

: 1566543-76-7
tert-butyl 4-(4-((4-(2-(1-carbamoylcyclopropyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen; triethylamine / N,N-dimethyl-formamide / 16 h

2.1: lithium hydroxide / tetrahydrofuran; water; methanol / 3.5 h / 20 - 40 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

3.2: 72 h / 40 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;