2,4-cis-4,6-cis-4-chloro-2,6-diphenyltetrahydropyran

Base Information

• Chemical Name: 2,4-cis-4,6-cis-4-chloro-2,6-diphenyltetrahydropyran
• CAS No.: 111396-34-0
• Molecular Formula: C₁₇H₁₇ClO
• Molecular Weight: 272.774
• Mol file: 111396-34-0.mol

Synonyms:2,4-cis-4,6-cis-4-chloro-2,6-diphenyltetrahydropyran

Chemical Property of 2,4-cis-4,6-cis-4-chloro-2,6-diphenyltetrahydropyran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2,4-cis-4,6-cis-4-chloro-2,6-diphenyltetrahydropyran

There total 12 articles about 2,4-cis-4,6-cis-4-chloro-2,6-diphenyltetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-Phenyl-3-buten-1-ol (80735-94-0,936-58-3) + N-(benzylidene)-p-methylbenzenesulfonamide (51608-60-7) → 2,4-cis-4,6-cis-4-chloro-2,6-diphenyltetrahydropyran (111396-34-0)

Guidance literature:

With bismuth(III) chloride; In dichloromethane; at 20 ℃; for 1.5h; stereoselective reaction;

DOI:10.1002/cjoc.201400450

Reference yield: 95.0%

1-Phenyl-3-buten-1-ol (80735-94-0,936-58-3) + benzaldehyde (100-52-7) → 2,4-cis-4,6-cis-4-chloro-2,6-diphenyltetrahydropyran (111396-34-0)

Guidance literature:

With 1-(n-butyl)-3-methylimidazolium tetrachloroaluminate; for 0.0833333h;

DOI:10.1002/ejoc.200210638

Reference yield: 72.0%

allyltributylstanane (24850-33-7) + benzaldehyde (100-52-7) → 2,4-cis-4,6-cis-4-chloro-2,6-diphenyltetrahydropyran (111396-34-0)

Guidance literature:

With indium(III) chloride; In dichloromethane; at 20 ℃;

DOI:10.1021/ol990789m

upstream raw materials:

benzaldehyde

allyl-trimethyl-silane

1-Phenyl-3-buten-1-ol

methoxybenzene