1-{3-bromo-4-[(2-[¹⁸F]fluoroethoxy)methyl]benzyl}guanidine trifluoroacetic acid salt

Base Information

• Chemical Name: 1-{3-bromo-4-[(2-[¹⁸F]fluoroethoxy)methyl]benzyl}guanidine trifluoroacetic acid salt
• CAS No.: 1427085-41-3
• Molecular Formula: C₂HF₃O₂*C₁₁H₁₅BrFN₃O
• Molecular Weight: 417.188

Synonyms:1-{3-bromo-4-[(2-[¹⁸F]fluoroethoxy)methyl]benzyl}guanidine trifluoroacetic acid salt

Chemical Property of 1-{3-bromo-4-[(2-[¹⁸F]fluoroethoxy)methyl]benzyl}guanidine trifluoroacetic acid salt

Chemical Property:

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Technology Process of 1-{3-bromo-4-[(2-[¹⁸F]fluoroethoxy)methyl]benzyl}guanidine trifluoroacetic acid salt

There total 6 articles about 1-{3-bromo-4-[(2-[¹⁸F]fluoroethoxy)methyl]benzyl}guanidine trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl [(Z)-{[3-bromo-4-(hydroxymethyl)benzyl]amino} {[( tert-butyloxy)carbonyl]amino}methylidene]carbamate (1427086-98-3) + trifluoroacetic acid (76-05-1) + [(18)F]-2-fluoroethyltosylate (113426-12-3) → 1-{3-bromo-4-[(2-[18F]fluoroethoxy)methyl]benzyl}guanidine trifluoroacetic acid salt (1427085-41-3)

Guidance literature:

tert-butyl [(Z)-{[3-bromo-4-(hydroxymethyl)benzyl]amino} {[( tert-butyloxy)carbonyl]amino}methylidene]carbamate; [⁽¹⁸⁾F]-2-fluoroethyltosylate; With potassium hydroxide; In dimethyl sulfoxide; at 80 ℃; for 0.75h;

trifluoroacetic acid; In dimethyl sulfoxide; at 50 ℃; for 0.25h;

Reference yield:

3-bromo-4-(hydroxymethyl)benzonitrile (90110-98-8) → 1-{3-bromo-4-[(2-[18F]fluoroethoxy)methyl]benzyl}guanidine trifluoroacetic acid salt (1427085-41-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran; methanol / 16 h / 0 - 20 °C

2.1: acetonitrile / 0.5 h / 20 °C

3.1: potassium hydroxide / dimethyl sulfoxide / 0.75 h / 80 °C

3.2: 0.25 h / 50 °C

With lithium aluminium tetrahydride; potassium hydroxide; In tetrahydrofuran; methanol; dimethyl sulfoxide; acetonitrile;

Reference yield:

3-bromo-4-formyl benzonitrile (89891-69-0) → 1-{3-bromo-4-[(2-[18F]fluoroethoxy)methyl]benzyl}guanidine trifluoroacetic acid salt (1427085-41-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate; methanol / 0.67 h / 0 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran; methanol / 16 h / 0 - 20 °C

3.1: acetonitrile / 0.5 h / 20 °C

4.1: potassium hydroxide / dimethyl sulfoxide / 0.75 h / 80 °C

4.2: 0.25 h / 50 °C

With methanol; sodium tetrahydroborate; lithium aluminium tetrahydride; potassium hydroxide; In tetrahydrofuran; methanol; dimethyl sulfoxide; acetonitrile;

upstream raw materials:

tert-butyl [(Z)-{[3-bromo-4-(hydroxymethyl)benzyl]amino} {[( tert-butyloxy)carbonyl]amino}methylidene]carbamate

trifluoroacetic acid

[(18)F]-2-fluoroethyltosylate

3-bromo-4-(dibromomethyl)benzonitrile

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