90110-98-8

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-4-cyanobenzyl alcohol is used as a building block for the production of certain drugs, contributing to the development of new pharmaceuticals due to its chemical properties and reactivity.
Used in Organic Chemistry Research:
In the field of organic chemistry, 2-Bromo-4-cyanobenzyl alcohol is used as a versatile compound for its ability to undergo various reactions, such as substitution and addition reactions, facilitating the exploration of new chemical pathways and the synthesis of novel organic compounds.
Used in Chemical Synthesis:
2-Bromo-4-cyanobenzyl alcohol is used as an intermediate in the manufacture of other organic compounds, playing a crucial role in the synthesis of complex organic molecules for various applications.
Safety Precautions:
Due to its potential hazards, including skin and eye irritation, 2-Bromo-4-cyanobenzyl alcohol should be handled with care. It is recommended to use it in a well-ventilated area and with proper personal protective equipment to ensure safety during its application in various industries.

Upstream product

• 557-21-1 zinc(II) cyanide 
• 666747-06-4 (2,4-dibromophenyl)methanol 
• 54335-33-0 methyl 2,4-dibromobenzoate 
• 611-00-7 2,4-dibromobenzoic acid 
• 104-85-8 para-methylbenzonitrile 
• 89891-69-0 3-bromo-4-formyl benzonitrile 
• 42872-74-2 3-bromo-4-methyl-benzonitrile 
• 1381846-22-5 3-bromo-4-(dibromomethyl)benzonitrile 
• 89892-39-7 3-bromo-4-(bromomethyl)benzonitrile 

Downstream Products

• 947162-60-9 1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole-6-carbonitrile 
• 1427086-31-4 [4-(aminomethyl)-2-bromophenyl]methanol 
• 1427086-98-3 tert-butyl [(Z)-{[3-bromo-4-(hydroxymethyl)benzyl]amino} {[( tert-butyloxy)carbonyl]amino}methylidene]carbamate 
• 1427085-35-5 1-[3-bromo-4-(fluoromethyl)benzyl]guanidine trfluoroacetic acid salt 
• 1427087-11-3 tert-butyl [(Z)-{[3-bromo-4-(bromomethyl)benzyl]amino} {[( tert-butyloxy)carbonyl]amino}methylidene]carbamate 
• 1427085-39-9 1-{3-bromo-4-[(2-fluoroethoxy)methyl]benzyl}guanidine trfluoroacetic acid salt 
• 1427085-41-3 1-{3-bromo-4-[(2-[¹⁸F]fluoroethoxy)methyl]benzyl}guanidine trifluoroacetic acid salt 
• 1361018-75-8 3-bromo-4-((tert-butyldimethylsilyloxy)methyl)benzonitrile 
• 1361018-81-6 3-bromo-4-((methoxymethoxy)methyl)styrene 
• 1361018-79-2 3-bromo-4-((tert-butyldimethylsilyloxy)methyl)styrene 
• 1361018-77-0 3-bromo-4-(((tert-butyldimethylsilyl)oxy)methyl)benzaldehyde 

Relevant academic research and scientific papers

PROTECTIVE GROUPS AND METHODS FOR PROTECTING BENZOXABOROLES OR OXABOROLES

The present invention relates in part protective groups that can be used to reversibly protect benzoxaboroles and/or oxaboroles and yield the corresponding protected complexes. The invention further relates to the use of these protective groups to protect benzoxaboroles and/or oxaboroles.

Protection of the Benzoxaborole Moiety: Synthesis and Functionalization of Zwitterionic Benzoxaborole Complexes

The synthesis and utility of three benzoxaborole protecting groups are reported. These protecting groups improve organic solubility and allow otherwise incompatible reactions (oxidations, substitutions, and mild reductions) to be achieved in the presence of the benzoxaborole moiety. 3-(N,N-Dimethylamino)-1-propanol was determined to be useful in one-step sequences and is readily cleaved upon workup. Two other groups, N-methylsalicylidenimine and 2-[1-(methylimino)ethyl]phenol, are suitable for multistep syntheses. Deprotection with mild aqueous acid allows for chromatography-free isolation of the benzoxaborole in high yields.

A general method for selective recognition of monosaccharides and oligosaccharides in water

Molecular recognition of carbohydrates plays vital roles in biology but has been difficult to achieve with synthetic receptors. Through covalent imprinting of carbohydrates in boroxole-functionalized cross-linked micelles, we prepared nanoparticle receptors for a wide variety of mono- and oligosaccharides. The boroxole functional monomer bound the sugar templates through cis-1,2-diol, cis-3,4-diol, and trans-4,6-diol. The protein-sized nanoparticles showed excellent selectivity for daldohexoses in water with submillimolar binding affinities and completely distinguished the three biologically important hexoses (glucose, mannose, and galactose). Glycosides with nonpolar aglycon showed stronger binding due to enhanced hydrophobic interactions. Oligosaccharides were distinguished on the basis of their monosaccharide building blocks, glycosidic linkages, chain length, as well as additional functional groups that could interact with the nanoparticles.

IMMUNE ADJUSTMENT COMPOUND, USE THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

The present invention provides a compound represented by formula I, wherein R is a halogen element or a C1-C6 alkyl group. The compound has S1 P1 receptor agonist activity and selective specificity and has obviously-shortened half-life in-vivo, and therefore the compound is a high-quality second-generation S1P1 receptor agonist. The present invention also provides a use of the compound in preparing medicine for treating diseases or symptoms mediated by an S1P1 receptor, a pharmaceutical composition comprising the compound, and uses of the compound and the pharmaceutical composition in treating diseases or symptoms mediated by the S1 P1 receptor.

2-ARYL SELENAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF

Disclosed are a 2-aryl selenazole compound and a pharmaceutical composition thereof, where the 2-aryl selenazole compound is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. The 2-aryl selenazole compound has the activi

COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS

The present invention relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, the

Monosaccharide-responsive release of insulin from polymersomes of polyboroxole block copolymers at neutral pH

We synthesized a boroxole-containing styrenic monomer that can be polymerized by the reversible addition-fragmentation and chain transfer (RAFT) method. Poly(styreneboroxole) (PBOx) and its block copolymers with a poly(ethylene glycol) (PEG) as a hydrophi

BORON-CONTAINING SMALL MOLECULES AS ANTIPROTOZOAL AGENTS

This invention provides novel compounds of the following formula useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.

Synthesis and biological evaluations of P4-benzoxaborole-substituted macrocyclic inhibitors of HCV NS3 protease

We disclose here a series of P4-benzoxaborole-substituted macrocyclic HCV protease inhibitors. These inhibitors are potent against HCV NS3 protease, their anti-HCV replicon potencies are largely impacted by substitutions on benzoxaborole ring system and P2 groups. P2 2-thiazole-isoquinoline provides best replicon potency. The in vitro SAR studies and in vivo PK evaluations of selected compounds are described herein.

BORON-CONTAINING SMALL MOLECULES AS ANTI-PROTOZOAL AGENTS

This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.