Technology Process of (1R,2S,3aS,4S,8S,8aR)-2-(tert-Butyl-diphenyl-silanyloxy)-7-ethoxy-4-methoxymethoxy-1,4-dimethyl-8-triethylsilanyloxy-1,2,3,3a,4,5,8,8a-octahydro-azulene
There total 22 articles about (1R,2S,3aS,4S,8S,8aR)-2-(tert-Butyl-diphenyl-silanyloxy)-7-ethoxy-4-methoxymethoxy-1,4-dimethyl-8-triethylsilanyloxy-1,2,3,3a,4,5,8,8a-octahydro-azulene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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663605-92-3
(1R,2S,3aS,4S,8S,8aR)-2-(tert-Butyl-diphenyl-silanyloxy)-7-ethoxy-4-methoxymethoxy-1,4-dimethyl-8-triethylsilanyloxy-1,2,3,3a,4,5,8,8a-octahydro-azulene
- Guidance literature:
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Grubbs' dihydroimidazoline ruthenium catalyst;
In
dichloromethane;
Heating;
DOI:10.1002/anie.200353140
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663605-92-3
(1R,2S,3aS,4S,8S,8aR)-2-(tert-Butyl-diphenyl-silanyloxy)-7-ethoxy-4-methoxymethoxy-1,4-dimethyl-8-triethylsilanyloxy-1,2,3,3a,4,5,8,8a-octahydro-azulene
- Guidance literature:
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Multi-step reaction with 2 steps
1: 1H-imidazole; dmap / N,N-dimethyl-formamide / 19 h / 20 °C
2: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 21 h / Heating
With
1H-imidazole; dmap;
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.200700302
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663605-92-3
(1R,2S,3aS,4S,8S,8aR)-2-(tert-Butyl-diphenyl-silanyloxy)-7-ethoxy-4-methoxymethoxy-1,4-dimethyl-8-triethylsilanyloxy-1,2,3,3a,4,5,8,8a-octahydro-azulene
- Guidance literature:
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Multi-step reaction with 4 steps
1: pyridine; Dess-Martin periodane / dichloromethane / 1 h / 20 °C
2: tert.-butyl lithium / tetrahydrofuran; pentane / -78 - 20 °C
3: 1H-imidazole; dmap / N,N-dimethyl-formamide / 19 h / 20 °C
4: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 21 h / Heating
With
pyridine; 1H-imidazole; dmap; tert.-butyl lithium; Dess-Martin periodane;
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; pentane;
DOI:10.1002/chem.200700302