tert-butyl 3-(4-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 3-(4-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate
• CAS No.: 1393900-92-9
• Molecular Formula: C₃₂H₃₇F₃N₄O₄
• Molecular Weight: 598.665

Synonyms:tert-butyl 3-(4-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

Chemical Property of tert-butyl 3-(4-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of tert-butyl 3-(4-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

There total 10 articles about tert-butyl 3-(4-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

tert-butyl 3-(4-((4-((2-(2-methoxy-2-oxoethyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate (1393900-91-8) → tert-butyl 3-(4-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate (1393900-92-9)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; ethyl acetate; at 20 ℃; for 42h; Inert atmosphere;

Reference yield:

3-pyridylboronic acid (1692-25-7) → tert-butyl 3-(4-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate (1393900-92-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: caesium carbonate / triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide / 18 h / 80 °C

2.1: hydrogenchloride; hydrogen / water; methanol / 48 h / 2068.65 Torr / Inert atmosphere

2.2: 20 h / 20 °C

3.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.5 h / 0 °C

3.2: 60 h / 0 - 20 °C

4.1: triethylamine / triphenylphosphine; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / microwave irradiation

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 42 h / 20 °C / Inert atmosphere

With hydrogenchloride; hydrogen; caesium carbonate; triethylamine; zinc(II) chloride; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; palladium 10% on activated carbon; palladium diacetate; triphenylphosphine; In methanol; diethyl ether; ethanol; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

p-nitrobenzene iodide (636-98-6) → tert-butyl 3-(4-((4-(2-(2-methoxy-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate (1393900-92-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: caesium carbonate / triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide / 18 h / 80 °C

2.1: hydrogenchloride; hydrogen / water; methanol / 48 h / 2068.65 Torr / Inert atmosphere

2.2: 20 h / 20 °C

3.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.5 h / 0 °C

3.2: 60 h / 0 - 20 °C

4.1: triethylamine / triphenylphosphine; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / microwave irradiation

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 42 h / 20 °C / Inert atmosphere

With hydrogenchloride; hydrogen; caesium carbonate; triethylamine; zinc(II) chloride; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; palladium 10% on activated carbon; palladium diacetate; triphenylphosphine; In methanol; diethyl ether; ethanol; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;

upstream raw materials:

3-pyridylboronic acid

p-nitrobenzene iodide

methyl (2-iodophenyl)acetate

3-(4'-nitrophenyl)pyridine

Downstream raw materials:

lithium 2-(2-(2-(2-((4-(1-(tert-butoxycarbonyl)piperidin-3-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetate

tert-butyl 3-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate

2-(2-(2-(2-((4-(piperidin-3-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

2-(2-(2-(2-((4-(1-methylpiperidin-3-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

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