Phosphoric acid 4-[(S)-2-acetylamino-2-((S)-1-dipentylcarbamoyl-3-methylsulfanyl-propylcarbamoyl)-ethyl]-phenyl ester di-tert-butyl ester

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Chemical Name:Phosphoric acid 4-[(S)-2-acetylamino-2-((S)-1-dipentylcarbamoyl-3-methylsulfanyl-propylcarbamoyl)-ethyl]-phenyl ester di-tert-butyl ester
CAS No.:205237-00-9
Molecular Formula:C₃₄H₆₀N₃O₇PS
Molecular Weight:685.906
Hs Code.:

Synonyms:Phosphoric acid 4-[(S)-2-acetylamino-2-((S)-1-dipentylcarbamoyl-3-methylsulfanyl-propylcarbamoyl)-ethyl]-phenyl ester di-tert-butyl ester

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Chemical Property of Phosphoric acid 4-[(S)-2-acetylamino-2-((S)-1-dipentylcarbamoyl-3-methylsulfanyl-propylcarbamoyl)-ethyl]-phenyl ester di-tert-butyl ester

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Technology Process of Phosphoric acid 4-[(S)-2-acetylamino-2-((S)-1-dipentylcarbamoyl-3-methylsulfanyl-propylcarbamoyl)-ethyl]-phenyl ester di-tert-butyl ester

There total 7 articles about Phosphoric acid 4-[(S)-2-acetylamino-2-((S)-1-dipentylcarbamoyl-3-methylsulfanyl-propylcarbamoyl)-ethyl]-phenyl ester di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2488-15-5
N-tert-butoxycarbonyl-L-methionine

: 205237-00-9
Phosphoric acid 4-[(S)-2-acetylamino-2-((S)-1-dipentylcarbamoyl-3-methylsulfanyl-propylcarbamoyl)-ethyl]-phenyl ester di-tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 4-methylmorpholine / tetrahydrofuran / 0.08 h / -20 °C

2: tetrahydrofuran / 3.5 h / -20 - 20 °C

3: 98 percent / HCl / dioxane; CH₂Cl₂ / 14 h

4: 81 percent / DCC, HOBT, Et₃N / CH₂Cl₂; dimethylformamide / 16 h / 0 - 20 °C

5: 97 percent / HCl / dioxane; CH₂Cl₂ / 3 h

6: 82 percent / DCC, HOBT, Et₃N / CH₂Cl₂; dimethylformamide / 18 h / 0 - 20 °C

7: 1.) NaH / 1.) THF, 0 deg C, 30 min, 2.) THF, from 0 deg C to RT, 16 h

With 4-methyl-morpholine; hydrogenchloride; sodium hydride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm970853a

Reference yield:

: 84890-95-9
C₁₅H₂₇NO₆S

: 205237-00-9
Phosphoric acid 4-[(S)-2-acetylamino-2-((S)-1-dipentylcarbamoyl-3-methylsulfanyl-propylcarbamoyl)-ethyl]-phenyl ester di-tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 3.5 h / -20 - 20 °C

2: 98 percent / HCl / dioxane; CH₂Cl₂ / 14 h

3: 81 percent / DCC, HOBT, Et₃N / CH₂Cl₂; dimethylformamide / 16 h / 0 - 20 °C

4: 97 percent / HCl / dioxane; CH₂Cl₂ / 3 h

5: 82 percent / DCC, HOBT, Et₃N / CH₂Cl₂; dimethylformamide / 18 h / 0 - 20 °C

6: 1.) NaH / 1.) THF, 0 deg C, 30 min, 2.) THF, from 0 deg C to RT, 16 h

With hydrogenchloride; sodium hydride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm970853a

Reference yield:

: 205236-89-1
((S)-1-Dipentylcarbamoyl-3-methylsulfanyl-propyl)-carbamic acid tert-butyl ester

: 205237-00-9
Phosphoric acid 4-[(S)-2-acetylamino-2-((S)-1-dipentylcarbamoyl-3-methylsulfanyl-propylcarbamoyl)-ethyl]-phenyl ester di-tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / HCl / dioxane; CH₂Cl₂ / 14 h

2: 81 percent / DCC, HOBT, Et₃N / CH₂Cl₂; dimethylformamide / 16 h / 0 - 20 °C

3: 97 percent / HCl / dioxane; CH₂Cl₂ / 3 h

4: 82 percent / DCC, HOBT, Et₃N / CH₂Cl₂; dimethylformamide / 18 h / 0 - 20 °C

5: 1.) NaH / 1.) THF, 0 deg C, 30 min, 2.) THF, from 0 deg C to RT, 16 h

With hydrogenchloride; sodium hydride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm970853a