(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-4-methylsulfanyl-N,N-dipentyl-butyramide

Base Information

Chemical Name:(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-4-methylsulfanyl-N,N-dipentyl-butyramide
CAS No.:190078-52-5
Molecular Formula:C₂₆H₄₃N₃O₄S
Molecular Weight:493.711
Hs Code.:

Synonyms:(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-4-methylsulfanyl-N,N-dipentyl-butyramide

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Chemical Property of (S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-4-methylsulfanyl-N,N-dipentyl-butyramide

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Technology Process of (S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-4-methylsulfanyl-N,N-dipentyl-butyramide

There total 6 articles about (S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-4-methylsulfanyl-N,N-dipentyl-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 64-19-7,77671-22-8
acetic acid

: (S)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-4-methylsulfanyl-N,N-dipentyl-butyramide; hydrochloride

: 190078-52-5
(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-4-methylsulfanyl-N,N-dipentyl-butyramide

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 18h;
DOI:10.1021/jm970853a

Reference yield:

: 2488-15-5
N-tert-butoxycarbonyl-L-methionine

: 190078-52-5
(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-4-methylsulfanyl-N,N-dipentyl-butyramide

Guidance literature:: Multi-step reaction with 6 steps

1: 4-methylmorpholine / tetrahydrofuran / 0.08 h / -20 °C

2: tetrahydrofuran / 3.5 h / -20 - 20 °C

3: 98 percent / HCl / dioxane; CH₂Cl₂ / 14 h

4: 81 percent / DCC, HOBT, Et₃N / CH₂Cl₂; dimethylformamide / 16 h / 0 - 20 °C

5: 97 percent / HCl / dioxane; CH₂Cl₂ / 3 h

6: 82 percent / DCC, HOBT, Et₃N / CH₂Cl₂; dimethylformamide / 18 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm970853a

Reference yield:

: 84890-95-9
C₁₅H₂₇NO₆S

: 190078-52-5
(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-4-methylsulfanyl-N,N-dipentyl-butyramide

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 3.5 h / -20 - 20 °C

2: 98 percent / HCl / dioxane; CH₂Cl₂ / 14 h

3: 81 percent / DCC, HOBT, Et₃N / CH₂Cl₂; dimethylformamide / 16 h / 0 - 20 °C

4: 97 percent / HCl / dioxane; CH₂Cl₂ / 3 h

5: 82 percent / DCC, HOBT, Et₃N / CH₂Cl₂; dimethylformamide / 18 h / 0 - 20 °C

With hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm970853a