N-tert-butyl-3-((4-(5-(3-phenylureido)pyrazine-2-carbonyl)piperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate

Base Information

Chemical Name:N-tert-butyl-3-((4-(5-(3-phenylureido)pyrazine-2-carbonyl)piperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate
CAS No.:1124214-45-4
Molecular Formula:C₂HF₃O₂*C₂₈H₃₃N₇O₃
Molecular Weight:629.639
Hs Code.:

Synonyms:N-tert-butyl-3-((4-(5-(3-phenylureido)pyrazine-2-carbonyl)piperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate

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Chemical Property of N-tert-butyl-3-((4-(5-(3-phenylureido)pyrazine-2-carbonyl)piperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate

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Technology Process of N-tert-butyl-3-((4-(5-(3-phenylureido)pyrazine-2-carbonyl)piperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate

There total 12 articles about N-tert-butyl-3-((4-(5-(3-phenylureido)pyrazine-2-carbonyl)piperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1124214-54-5
3-((4-(2-aminopyrazine-5-carbonyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

: 103-71-9
phenyl isocyanate

: 1124214-45-4
N-tert-butyl-3-((4-(5-(3-phenylureido)pyrazine-2-carbonyl)piperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate

Guidance literature:: In 1,4-dioxane; at 70 ℃;

Reference yield:

: 122-05-4
2,5-pyrazinedicarboxylic acid

: 1124214-45-4
N-tert-butyl-3-((4-(5-(3-phenylureido)pyrazine-2-carbonyl)piperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride / 48 h / 80 °C / sealed vessel

2.1: hydrazine hydrate / ethanol / 20 °C

3.1: hydrogenchloride; sodium nitrite / dichloromethane; water / 1 h / 0 - 10 °C

4.1: toluene / 1 h / Reflux

5.1: water; potassium hydroxide / methanol / 20 °C

5.2: pH 2

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

6.2: 20 °C

7.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

8.1: 1,4-dioxane / 70 °C

With hydrogenchloride; water; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; potassium hydroxide; sodium nitrite; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1094362-66-9
N-tert-butyl-3-(chloromethyl)benzamide

: 1124214-45-4
N-tert-butyl-3-((4-(5-(3-phenylureido)pyrazine-2-carbonyl)piperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 20 °C / Inert atmosphere

2.1: hydrogenchloride / ethanol / 4 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 20 °C

4.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

5.1: 1,4-dioxane / 70 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In 1,4-dioxane; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;