N-(5-Chloro-2-pyrimidinyl)-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-N-methoxyacetyl-2-methyl benzoic acid amide

Base Information

Chemical Name:N-(5-Chloro-2-pyrimidinyl)-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-N-methoxyacetyl-2-methyl benzoic acid amide
CAS No.:928782-92-7
Molecular Formula:C₂₅H₁₈Cl₃F₃N₄O₄
Molecular Weight:601.797
Hs Code.:

Synonyms:N-(5-Chloro-2-pyrimidinyl)-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-N-methoxyacetyl-2-methyl benzoic acid amide

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Chemical Property of N-(5-Chloro-2-pyrimidinyl)-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-N-methoxyacetyl-2-methyl benzoic acid amide

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Technology Process of N-(5-Chloro-2-pyrimidinyl)-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-N-methoxyacetyl-2-methyl benzoic acid amide

There total 6 articles about N-(5-Chloro-2-pyrimidinyl)-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-N-methoxyacetyl-2-methyl benzoic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67492-50-6
(3,5-dichlorophenyl)boronic acid

: 928782-92-7
N-(5-Chloro-2-pyrimidinyl)-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-N-methoxyacetyl-2-methyl benzoic acid amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water / 3 h / Heating / reflux

2.1: potassium hydrogencarbonate / tetrahydrofuran / 5 h / Heating / reflux

3.1: sodium acetate / palladium diacetate; triphenylphosphine / 1,2-dimethoxyethane; water / 7 h / 110 °C / 11251.1 Torr

3.2: 1.5 h / 80 °C

4.1: pyridine / 23 h / 20 °C

4.2: 1.5 h / 20 °C

5.1: triethylamine / dmap / tetrahydrofuran / 0.5 h / 20 °C

With pyridine; sodium acetate; potassium carbonate; potassium hydrogencarbonate; triethylamine; dmap; bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; water;

Reference yield:

: 864725-22-4
1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: 928782-92-7
N-(5-Chloro-2-pyrimidinyl)-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-N-methoxyacetyl-2-methyl benzoic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydrogencarbonate / tetrahydrofuran / 5 h / Heating / reflux

2.1: sodium acetate / palladium diacetate; triphenylphosphine / 1,2-dimethoxyethane; water / 7 h / 110 °C / 11251.1 Torr

2.2: 1.5 h / 80 °C

3.1: pyridine / 23 h / 20 °C

3.2: 1.5 h / 20 °C

4.1: triethylamine / dmap / tetrahydrofuran / 0.5 h / 20 °C

With pyridine; sodium acetate; potassium hydrogencarbonate; triethylamine; dmap; palladium diacetate; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; water;

Reference yield:

: 5-(3,5-dichloro-phenyl)-3-(4-bromo-3-methyl-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazole

: 928782-92-7
N-(5-Chloro-2-pyrimidinyl)-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-N-methoxyacetyl-2-methyl benzoic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium acetate / palladium diacetate; triphenylphosphine / 1,2-dimethoxyethane; water / 7 h / 110 °C / 11251.1 Torr

1.2: 1.5 h / 80 °C

2.1: pyridine / 23 h / 20 °C

2.2: 1.5 h / 20 °C

3.1: triethylamine / dmap / tetrahydrofuran / 0.5 h / 20 °C

With pyridine; sodium acetate; triethylamine; dmap; palladium diacetate; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; water;