7-(4-Bromo-2-fluoro-phenylamino)-6-fluoro-5-oxo-1,2,3,1-tetrahydro-indolizine-8-carbaldehyde

Base Information

Chemical Name:7-(4-Bromo-2-fluoro-phenylamino)-6-fluoro-5-oxo-1,2,3,1-tetrahydro-indolizine-8-carbaldehyde
CAS No.:1193488-72-0
Molecular Formula:C₁₅H₁₁BrF₂N₂O₂
Molecular Weight:369.165
Hs Code.:

Synonyms:7-(4-Bromo-2-fluoro-phenylamino)-6-fluoro-5-oxo-1,2,3,1-tetrahydro-indolizine-8-carbaldehyde

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Chemical Property of 7-(4-Bromo-2-fluoro-phenylamino)-6-fluoro-5-oxo-1,2,3,1-tetrahydro-indolizine-8-carbaldehyde

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Technology Process of 7-(4-Bromo-2-fluoro-phenylamino)-6-fluoro-5-oxo-1,2,3,1-tetrahydro-indolizine-8-carbaldehyde

There total 1 articles about 7-(4-Bromo-2-fluoro-phenylamino)-6-fluoro-5-oxo-1,2,3,1-tetrahydro-indolizine-8-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.16%

: 1193488-71-9
7-(4-bromo-2-fluoro-phenylamino)-6-fluoro-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid methoxy-methyl-amide

: 1193488-72-0
7-(4-Bromo-2-fluoro-phenylamino)-6-fluoro-5-oxo-1,2,3,1-tetrahydro-indolizine-8-carbaldehyde

Guidance literature:: 7-(4-bromo-2-fluoro-phenylamino)-6-fluoro-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid methoxy-methyl-amide; With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at -78 ℃; for 2h;

With ammonium chloride; In tetrahydrofuran; toluene;

Reference yield: 9.0%

: 1193488-72-0
7-(4-Bromo-2-fluoro-phenylamino)-6-fluoro-5-oxo-1,2,3,1-tetrahydro-indolizine-8-carbaldehyde

: 1826-67-1
vinyl magnesium bromide

: 1193487-90-9
7-(4-bromo-2-fluoro-phenylamino)-6-fluoro-8-(1-hydroxy-allyl)-2,3-dihydro-1H-indolizin-5-one

Guidance literature:: In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

Reference yield:

: 1193488-72-0
7-(4-Bromo-2-fluoro-phenylamino)-6-fluoro-5-oxo-1,2,3,1-tetrahydro-indolizine-8-carbaldehyde

: 100045-83-8
tributyl({[(methyloxy)methyl]oxy}methyl)stannane

: 1193489-10-9
7-(4-bromo-2-fluoro-phenylamino)-6-fluoro-8-(1-hydroxy-2-methoxymethoxy-ethyl)-2,3-dihydro-1H-indolizin-5-one

Guidance literature:: tributyl({[(methyloxy)methyl]oxy}methyl)stannane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;

7-(4-Bromo-2-fluoro-phenylamino)-6-fluoro-5-oxo-1,2,3,1-tetrahydro-indolizine-8-carbaldehyde; In tetrahydrofuran; hexane; at -78 ℃; for 0.666667h;