7-(4-bromo-2-fluoro-phenylamino)-6-fluoro-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid methoxy-methyl-amide

Base Information

Chemical Name:7-(4-bromo-2-fluoro-phenylamino)-6-fluoro-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid methoxy-methyl-amide
CAS No.:1193488-71-9
Molecular Formula:C₁₇H₁₆BrF₂N₃O₃
Molecular Weight:428.233
Hs Code.:

Synonyms:7-(4-bromo-2-fluoro-phenylamino)-6-fluoro-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid methoxy-methyl-amide

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Chemical Property of 7-(4-bromo-2-fluoro-phenylamino)-6-fluoro-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid methoxy-methyl-amide

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Technology Process of 7-(4-bromo-2-fluoro-phenylamino)-6-fluoro-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid methoxy-methyl-amide

There total 1 articles about 7-(4-bromo-2-fluoro-phenylamino)-6-fluoro-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid methoxy-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.7%

: 1193487-39-6
7-(4-bromo-2-fluoro-phenylamino)-6-fluoro-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 1193488-71-9
7-(4-bromo-2-fluoro-phenylamino)-6-fluoro-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid methoxy-methyl-amide

Guidance literature:: 7-(4-bromo-2-fluoro-phenylamino)-6-fluoro-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 1.3h;

N,O-dimethylhydroxylamine*hydrochloride; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;

Reference yield: 33.16%

: 1193488-71-9
7-(4-bromo-2-fluoro-phenylamino)-6-fluoro-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid methoxy-methyl-amide

: 1193488-72-0
7-(4-Bromo-2-fluoro-phenylamino)-6-fluoro-5-oxo-1,2,3,1-tetrahydro-indolizine-8-carbaldehyde

Guidance literature:: 7-(4-bromo-2-fluoro-phenylamino)-6-fluoro-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid methoxy-methyl-amide; With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at -78 ℃; for 2h;

With ammonium chloride; In tetrahydrofuran; toluene;