methyl trans-4-[1-tert-butoxycarbonyl-(5R)-methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

Base Information

Chemical Name:methyl trans-4-[1-tert-butoxycarbonyl-(5R)-methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate
CAS No.:1416961-08-4
Molecular Formula:C₁₉H₃₃NO₅
Molecular Weight:355.475
Hs Code.:

Synonyms:methyl trans-4-[1-tert-butoxycarbonyl-(5R)-methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

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Chemical Property of methyl trans-4-[1-tert-butoxycarbonyl-(5R)-methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

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Technology Process of methyl trans-4-[1-tert-butoxycarbonyl-(5R)-methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

There total 5 articles about methyl trans-4-[1-tert-butoxycarbonyl-(5R)-methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: C₁₈H₃₁NO₅

: 1416961-08-4
methyl trans-4-[1-tert-butoxycarbonyl-(5R)-methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

Guidance literature:: With diazomethyl-trimethyl-silane; In hexane; benzene; at 20 ℃; for 16h;
DOI:10.1016/j.bmc.2012.11.003

Reference yield:

: 99-76-3,156291-94-0
methyl 4-hydroxylbenzoate

: 1416961-08-4
methyl trans-4-[1-tert-butoxycarbonyl-(5R)-methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / 2 h / 60 °C

2: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3: Rh/Al₂O₃; hydrogen / methanol / 5 h / 20?atm

4: triethylamine / acetonitrile; water / 14 h / 20 °C

5: sodium methylate / methanol / 18 h / Inert atmosphere; Reflux

6: diazomethyl-trimethyl-silane / benzene; hexane / 16 h / 20 °C

With di-isopropyl azodicarboxylate; Rh/Al₂O₃; hydrogen; sodium methylate; triethylamine; triphenylphosphine; trifluoroacetic acid; diazomethyl-trimethyl-silane; In methanol; hexane; dichloromethane; water; acetonitrile; benzene; 1: |Mitsunobu Displacement;
DOI:10.1016/j.bmc.2012.11.003

Reference yield:

: 317357-96-3
methyl 4-[1-tert-butoxycarbonyl-(5R)-methyl-(2S)-pyrrolidinylmethoxy]benzoate

: 1416961-08-4
methyl trans-4-[1-tert-butoxycarbonyl-(5R)-methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

2: Rh/Al₂O₃; hydrogen / methanol / 5 h / 20?atm

3: triethylamine / acetonitrile; water / 14 h / 20 °C

4: sodium methylate / methanol / 18 h / Inert atmosphere; Reflux

5: diazomethyl-trimethyl-silane / benzene; hexane / 16 h / 20 °C

With Rh/Al₂O₃; hydrogen; sodium methylate; triethylamine; trifluoroacetic acid; diazomethyl-trimethyl-silane; In methanol; hexane; dichloromethane; water; acetonitrile; benzene;
DOI:10.1016/j.bmc.2012.11.003