methyl 4-[(2S,4aR,10bR)-9-ethoxy-8-methoxy-2-oxido-3,4,4a,10b-tetrahydro-1H-thiopyrano[4,3-c]isoquinolin-6-yl]benzoate

Base Information

Chemical Name:methyl 4-[(2S,4aR,10bR)-9-ethoxy-8-methoxy-2-oxido-3,4,4a,10b-tetrahydro-1H-thiopyrano[4,3-c]isoquinolin-6-yl]benzoate
CAS No.:1312600-87-5
Molecular Formula:C₂₃H₂₅NO₅S
Molecular Weight:427.521
Hs Code.:

Synonyms:methyl 4-[(2S,4aR,10bR)-9-ethoxy-8-methoxy-2-oxido-3,4,4a,10b-tetrahydro-1H-thiopyrano[4,3-c]isoquinolin-6-yl]benzoate

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Chemical Property of methyl 4-[(2S,4aR,10bR)-9-ethoxy-8-methoxy-2-oxido-3,4,4a,10b-tetrahydro-1H-thiopyrano[4,3-c]isoquinolin-6-yl]benzoate

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Technology Process of methyl 4-[(2S,4aR,10bR)-9-ethoxy-8-methoxy-2-oxido-3,4,4a,10b-tetrahydro-1H-thiopyrano[4,3-c]isoquinolin-6-yl]benzoate

There total 7 articles about methyl 4-[(2S,4aR,10bR)-9-ethoxy-8-methoxy-2-oxido-3,4,4a,10b-tetrahydro-1H-thiopyrano[4,3-c]isoquinolin-6-yl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312600-95-5
methyl 4-[(4aR,10bR)-9-ethoxy-8-methoxy-3,4,4a,10b-tetrahydro-1H-thiopyrano[4,3-c]isoquinolin-6-yl]benzoate

: 1312600-86-4
methyl 4-[(2R,4aR,10bR)-9-ethoxy-8-methoxy-2-oxido-3,4,4a,10b-tetrahydro-1H-thiopyrano[4,3-c]isoquinolin-6-yl]benzoate

: 1312600-87-5
methyl 4-[(2S,4aR,10bR)-9-ethoxy-8-methoxy-2-oxido-3,4,4a,10b-tetrahydro-1H-thiopyrano[4,3-c]isoquinolin-6-yl]benzoate

: 1312600-88-6
methyl 4-[(4aR,10bR)-9-ethoxy-8-methoxy-2,2-dioxido-3,4,4a,10b-tetrahydro-1H-thiopyrano[4,3-c]isoquinolin-6-yl]benzoate

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -50 ℃; Inert atmosphere;

Reference yield:

: 7377-26-6
4-Methoxycarbonylbenzoyl chloride

: 1312600-86-4
methyl 4-[(2R,4aR,10bR)-9-ethoxy-8-methoxy-2-oxido-3,4,4a,10b-tetrahydro-1H-thiopyrano[4,3-c]isoquinolin-6-yl]benzoate

: 1312600-87-5
methyl 4-[(2S,4aR,10bR)-9-ethoxy-8-methoxy-2-oxido-3,4,4a,10b-tetrahydro-1H-thiopyrano[4,3-c]isoquinolin-6-yl]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

2: potassium carbonate; trichlorophosphate / acetonitrile / 17 h / 0 °C / Reflux

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / -50 °C / Inert atmosphere

With potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In dichloromethane; acetonitrile;

Reference yield:

: 882030-14-0
3-(3-ethoxy-4-methoxyphenyl)tetrahydrothiopyran-4-one

: 1312600-86-4
methyl 4-[(2R,4aR,10bR)-9-ethoxy-8-methoxy-2-oxido-3,4,4a,10b-tetrahydro-1H-thiopyrano[4,3-c]isoquinolin-6-yl]benzoate

: 1312600-87-5
methyl 4-[(2S,4aR,10bR)-9-ethoxy-8-methoxy-2-oxido-3,4,4a,10b-tetrahydro-1H-thiopyrano[4,3-c]isoquinolin-6-yl]benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 15 h / 20 °C

1.2: 20 - 60 °C

2.1: trifluoroacetic acid / 0.5 h / 20 °C

2.2: 20 °C / pH 10

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

4.1: potassium carbonate; trichlorophosphate / acetonitrile / 17 h / 0 °C / Reflux

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / -50 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; trichlorophosphate; In dichloromethane; acetonitrile;