Technology Process of N4-p-bromobenzoylcytidine
There total 1 articles about N4-p-bromobenzoylcytidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
CYTIDINE;
With
pyridine; chloro-trimethyl-silane;
at 20 ℃;
for 2h;
4-chlorobenzoyl chloride;
for 2h;
With
ammonia;
In
water;
at 0 ℃;
for 0.5h;
DOI:10.1021/ol301769j
- Guidance literature:
-
N4-p-bromobenzoylcytidine; acetone;
With
perchloric acid;
at 20 ℃;
for 1.5h;
With
ammonia;
In
water;
for 0.25h;
DOI:10.1021/ol301769j
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: perchloric acid / 1.5 h / 20 °C
1.2: 0.25 h
2.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / tetrahydrofuran / 0.75 h / 0 °C
With
perchloric acid; di-isopropyl azodicarboxylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; lithium chloride;
In
tetrahydrofuran; dichloromethane;
2.1: Mitsunobu reaction;
DOI:10.1021/ol301769j
