2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-l,4'-l',2',3',4'-tetrahydroquinoline)-6-carboxylic acid methyl ester

Base Information

Chemical Name:2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-l,4'-l',2',3',4'-tetrahydroquinoline)-6-carboxylic acid methyl ester
CAS No.:1353970-91-8
Molecular Formula:C₂₀H₂₀FNO₂
Molecular Weight:325.383
Hs Code.:

Synonyms:2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-l,4'-l',2',3',4'-tetrahydroquinoline)-6-carboxylic acid methyl ester

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Chemical Property of 2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-l,4'-l',2',3',4'-tetrahydroquinoline)-6-carboxylic acid methyl ester

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Technology Process of 2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-l,4'-l',2',3',4'-tetrahydroquinoline)-6-carboxylic acid methyl ester

There total 1 articles about 2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-l,4'-l',2',3',4'-tetrahydroquinoline)-6-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1353970-87-2
4-[(5-fluoro-2-methyl-benzylidene)-amino]-benzoic acid methyl ester

: 6142-73-0
methylene cyclopropane

: 1353970-91-8
2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-l,4'-l',2',3',4'-tetrahydroquinoline)-6-carboxylic acid methyl ester

Guidance literature:: scandium tris(trifluoromethanesulfonate); In acetonitrile; at 80 ℃; for 16h; Sealed tube;

Reference yield: 85.0%

: 1353970-91-8
2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-l,4'-l',2',3',4'-tetrahydroquinoline)-6-carboxylic acid methyl ester

: 1353968-56-5
2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-1,4'-1',2',3',4'-tetrahydroquinoline)-6-carboxylic acid

Guidance literature:: 2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-l,4'-l',2',3',4'-tetrahydroquinoline)-6-carboxylic acid methyl ester; With methanol; sodium hydroxide; In tetrahydrofuran; at 80 ℃; for 6h;

With hydrogenchloride; In water; pH=4;

Reference yield:

: 1353970-91-8
2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-l,4'-l',2',3',4'-tetrahydroquinoline)-6-carboxylic acid methyl ester

: 1391608-78-8
2'-(5-Fluoro-2-methylphenyl)-N-(methylsulfonyl)-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-quinoline]-6'-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / tetrahydrofuran; methanol / 6 h / 80 °C

1.2: pH 4

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 25 °C

2.2: 2 h / 25 - 70 °C

With sodium hydride; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;