8-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-4-hydroxy-3-methoxy-8-oxo-7,9,18-trioxa-1,15-diaza-8λ⁵-phospha-tricyclo[11.3.1.1^2,5]octadec-13(17)-ene-14,16-dione

Base Information

• Chemical Name: 8-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-4-hydroxy-3-methoxy-8-oxo-7,9,18-trioxa-1,15-diaza-8λ⁵-phospha-tricyclo[11.3.1.1^2,5]octadec-13(17)-ene-14,16-dione
• CAS No.: 352320-09-3
• Molecular Formula: C₄₄H₄₉N₄O₁₅P
• Molecular Weight: 904.865

Synonyms:8-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-4-hydroxy-3-methoxy-8-oxo-7,9,18-trioxa-1,15-diaza-8λ⁵-phospha-tricyclo[11.3.1.1^2,5]octadec-13(17)-ene-14,16-dione

Chemical Property of 8-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-4-hydroxy-3-methoxy-8-oxo-7,9,18-trioxa-1,15-diaza-8λ⁵-phospha-tricyclo[11.3.1.1^2,5]octadec-13(17)-ene-14,16-dione

Chemical Property:

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Technology Process of 8-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-4-hydroxy-3-methoxy-8-oxo-7,9,18-trioxa-1,15-diaza-8λ⁵-phospha-tricyclo[11.3.1.1^2,5]octadec-13(17)-ene-14,16-dione

There total 4 articles about 8-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-4-hydroxy-3-methoxy-8-oxo-7,9,18-trioxa-1,15-diaza-8λ⁵-phospha-tricyclo[11.3.1.1^2,5]octadec-13(17)-ene-14,16-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C46H51N4O16P (352320-08-2) → 8-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-4-hydroxy-3-methoxy-8-oxo-7,9,18-trioxa-1,15-diaza-8λ5-phospha-tricyclo[11.3.1.12,5]octadec-13(17)-ene-14,16-dione (352320-09-3)

Guidance literature:

With ammonium hydroxide; In pyridine; at 20 ℃; for 3h;

DOI:10.1002/1099-0690(200105)2001:10<1989::aid-ejoc1989>3.0.co;2-h

Reference yield:

5‘-O-dimethoxytrityl-2’-deoxyribothymidine 3‘-O-phosphorodiamidite (104655-84-7) → 8-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-4-hydroxy-3-methoxy-8-oxo-7,9,18-trioxa-1,15-diaza-8λ5-phospha-tricyclo[11.3.1.12,5]octadec-13(17)-ene-14,16-dione (352320-09-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1H-tetrazole / acetonitrile; dioxane / 2.5 h / 20 °C

2: 403 mg / tBuOOH / acetonitrile; dioxane / 1 h / 20 °C

3: 90 percent / aq. NH₃ / pyridine / 3 h / 20 °C

With 1H-tetrazole; tert.-butylhydroperoxide; ammonium hydroxide; In 1,4-dioxane; pyridine; acetonitrile;

DOI:10.1002/1099-0690(200105)2001:10<1989::aid-ejoc1989>3.0.co;2-h

Reference yield:

5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) → 8-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-4-hydroxy-3-methoxy-8-oxo-7,9,18-trioxa-1,15-diaza-8λ5-phospha-tricyclo[11.3.1.12,5]octadec-13(17)-ene-14,16-dione (352320-09-3)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₃N / dioxane / 0.5 h / 20 °C

2: 1H-tetrazole / acetonitrile; dioxane / 2.5 h / 20 °C

3: 403 mg / tBuOOH / acetonitrile; dioxane / 1 h / 20 °C

4: 90 percent / aq. NH₃ / pyridine / 3 h / 20 °C

With 1H-tetrazole; tert.-butylhydroperoxide; ammonium hydroxide; triethylamine; In 1,4-dioxane; pyridine; acetonitrile;

DOI:10.1002/1099-0690(200105)2001:10<1989::aid-ejoc1989>3.0.co;2-h

upstream raw materials:

C₄₆H₅₁N₄O₁₆P

5‘-O-dimethoxytrityl-2’-deoxyribothymidine 3‘-O-phosphorodiamidite

5'-O-(4-4'-dimethoxytrityl)thymidine

Downstream raw materials:

C₅₃H₆₆N₆O₁₆P₂

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