methyl{[2'-(3''-phenylprop-1''-ynyl)cyclohex-1'-en-1'-yl]methylene}amine N-oxide

Base Information

• Chemical Name: methyl{[2'-(3''-phenylprop-1''-ynyl)cyclohex-1'-en-1'-yl]methylene}amine N-oxide
• CAS No.: 863498-66-2
• Molecular Formula: C₁₇H₁₉NO
• Molecular Weight: 253.344
• Mol file: 863498-66-2.mol

Synonyms:methyl{[2'-(3''-phenylprop-1''-ynyl)cyclohex-1'-en-1'-yl]methylene}amine N-oxide

Chemical Property of methyl{[2'-(3''-phenylprop-1''-ynyl)cyclohex-1'-en-1'-yl]methylene}amine N-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of methyl{[2'-(3''-phenylprop-1''-ynyl)cyclohex-1'-en-1'-yl]methylene}amine N-oxide

There total 3 articles about methyl{[2'-(3''-phenylprop-1''-ynyl)cyclohex-1'-en-1'-yl]methylene}amine N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-(3'-phenylprop-1'-ynyl)cyclohex-1-ene-1-carbaldehyde (863498-62-8) + N-methylhydroxyamine hydrochloride (4229-44-1) → methyl{[2'-(3''-phenylprop-1''-ynyl)cyclohex-1'-en-1'-yl]methylene}amine N-oxide (863498-66-2)

Guidance literature:

With sodium acetate; In dichloromethane; at 20 ℃; for 22h;

DOI:10.1002/ejoc.200400922

Reference yield:

propargyl benzene (10147-11-2) → methyl{[2'-(3''-phenylprop-1''-ynyl)cyclohex-1'-en-1'-yl]methylene}amine N-oxide (863498-66-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / CuI; NEt₃ / PdCl₂(PPh₃)2 / benzene / 4 h / 20 °C

2: 72 percent / NaOAc / CH₂Cl₂ / 22 h / 20 °C

With copper(l) iodide; sodium acetate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; benzene; 1: Sonogashira reaction;

DOI:10.1002/ejoc.200400922

Reference yield:

2-bromocyclohex-1-ene-1-carbaldehyde (38127-47-8) → methyl{[2'-(3''-phenylprop-1''-ynyl)cyclohex-1'-en-1'-yl]methylene}amine N-oxide (863498-66-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / CuI; NEt₃ / PdCl₂(PPh₃)2 / benzene / 4 h / 20 °C

2: 72 percent / NaOAc / CH₂Cl₂ / 22 h / 20 °C

With copper(l) iodide; sodium acetate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; benzene; 1: Sonogashira reaction;

DOI:10.1002/ejoc.200400922

upstream raw materials:

2-(3'-phenylprop-1'-ynyl)cyclohex-1-ene-1-carbaldehyde

N-methylhydroxyamine hydrochloride

propargyl benzene

2-bromocyclohex-1-ene-1-carbaldehyde

Downstream raw materials:

2-methyl-4-phenyl-2,4,6,7,8,9-hexahydrocyclopenta-3H-2-benzazepin-3-one