Trans-N-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-N,N-dimethyl-sulfamide

Base Information

Chemical Name:Trans-N-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-N,N-dimethyl-sulfamide
CAS No.:1395922-20-9
Molecular Formula:C₂₂H₃₅N₃O₄S
Molecular Weight:437.604
Hs Code.:

Synonyms:Trans-N-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-N,N-dimethyl-sulfamide

Suppliers and Price of Trans-N-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-N,N-dimethyl-sulfamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Trans-N-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-N,N-dimethyl-sulfamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Trans-N-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-N,N-dimethyl-sulfamide

There total 6 articles about Trans-N-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-N,N-dimethyl-sulfamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.7%

: trans-4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexylamine hydrochloride

: 13360-57-1
dimethylamino sulfonyl chloride

: 1395922-20-9
Trans-N-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-N,N-dimethyl-sulfamide

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; In acetonitrile; at 20 ℃; for 24h;

Reference yield:

: 6698-13-1
4-bromo-benzo[1,3]dioxole

: 1395922-20-9
Trans-N-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-N,N-dimethyl-sulfamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine; sodium carbonate / palladium diacetate / 1,2-dimethoxyethane / 85 °C / Inert atmosphere

2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

3.1: ammonium formate / palladium 10% on activated carbon / methanol / 1 h / Inert atmosphere; Reflux

4.1: dichloromethane; methanol / 2 h / 20 °C

4.2: 16 h / 20 °C

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

6.1: 1,4-diaza-bicyclo[2.2.2]octane / acetonitrile / 24 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; ammonium formate; sodium carbonate; triphenylphosphine; palladium 10% on activated carbon; palladium diacetate; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; acetonitrile;

Reference yield:

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 1395922-20-9
Trans-N-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-N,N-dimethyl-sulfamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine; sodium carbonate / palladium diacetate / 1,2-dimethoxyethane / 85 °C / Inert atmosphere

2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

3.1: ammonium formate / palladium 10% on activated carbon / methanol / 1 h / Inert atmosphere; Reflux

4.1: dichloromethane; methanol / 2 h / 20 °C

4.2: 16 h / 20 °C

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

6.1: 1,4-diaza-bicyclo[2.2.2]octane / acetonitrile / 24 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; ammonium formate; sodium carbonate; triphenylphosphine; palladium 10% on activated carbon; palladium diacetate; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; acetonitrile;