Toluene-4-sulfonic acid (2S,4S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-ylmethyl ester

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Chemical Name:Toluene-4-sulfonic acid (2S,4S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-ylmethyl ester
CAS No.:196861-67-3
Molecular Formula:C₁₉H₂₂O₆S
Molecular Weight:378.446
Hs Code.:

Synonyms:Toluene-4-sulfonic acid (2S,4S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-ylmethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Toluene-4-sulfonic acid (2S,4S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-ylmethyl ester

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Technology Process of Toluene-4-sulfonic acid (2S,4S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-ylmethyl ester

There total 2 articles about Toluene-4-sulfonic acid (2S,4S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 103708-37-8
(2S,4S)-4-hydroxymethyl-2-(p-methoxymethyl)-1,3-dioxane

: 98-59-9
p-toluenesulfonyl chloride

: 196861-67-3
Toluene-4-sulfonic acid (2S,4S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-ylmethyl ester

Guidance literature:: With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In dichloromethane; for 18h; Ambient temperature;
DOI:10.1016/S0040-4039(97)01523-2

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 196861-67-3
Toluene-4-sulfonic acid (2S,4S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) TMSTf; 2.) NaOH / 1.) CH₂Cl₂, -78 deg C; 2.) MeOH, 0 deg C

2: 93 percent / TEBA-Cl, 30percent aq. sodium hydroxide / CH₂Cl₂ / 18 h / Ambient temperature

With sodium hydroxide; TMSTf; N-benzyl-N,N,N-triethylammonium chloride; In dichloromethane;
DOI:10.1016/S0040-4039(97)01523-2

Reference yield:

: 196861-67-3
Toluene-4-sulfonic acid (2S,4S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-ylmethyl ester

: 186378-98-3
(2S,4R)-2-(4-methoxyphenyl)-4-methyl-1,3-dioxane

Guidance literature:: Multi-step reaction with 2 steps

1: dimethylformamide / 3 h / Ambient temperature

2: Raney nickel / aq. ethanol / 12 h / Ambient temperature

With nickel; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(97)01523-2