5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-1,2,3,4,7,8-hexahydropyrimido[4,5-a]indolizin-10-yl trifluoromethanesulfonate

Base Information

Chemical Name:5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-1,2,3,4,7,8-hexahydropyrimido[4,5-a]indolizin-10-yl trifluoromethanesulfonate
CAS No.:1614251-45-4
Molecular Formula:C₂₀H₁₅F₃N₄O₅S
Molecular Weight:480.424
Hs Code.:

Synonyms:5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-1,2,3,4,7,8-hexahydropyrimido[4,5-a]indolizin-10-yl trifluoromethanesulfonate

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Chemical Property of 5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-1,2,3,4,7,8-hexahydropyrimido[4,5-a]indolizin-10-yl trifluoromethanesulfonate

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Technology Process of 5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-1,2,3,4,7,8-hexahydropyrimido[4,5-a]indolizin-10-yl trifluoromethanesulfonate

There total 9 articles about 5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-1,2,3,4,7,8-hexahydropyrimido[4,5-a]indolizin-10-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 358-23-6
trifluoromethylsulfonic anhydride

: 1614251-44-3
3-(1,3-dimethyl-2,4,10-trioxo-1,2,3,4,7,8,9,10-octahydropyrimido[4,5-a]indolizin-5-yl)benzonitrile

: 1614251-45-4
5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-1,2,3,4,7,8-hexahydropyrimido[4,5-a]indolizin-10-yl trifluoromethanesulfonate

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; for 2h; Cooling with ice;

Reference yield:

: 1613623-81-6
1,3-dimethyl-2,4-dioxo-6-((2-(trimethylsilyl)ethoxy)methyl)-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-ylboronic acid

: 1614251-45-4
5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-1,2,3,4,7,8-hexahydropyrimido[4,5-a]indolizin-10-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / acetic acid butyl ester; water / 1.5 h / 80 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 60 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

4.1: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C

4.2: pH 1

5.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / N,N-dimethyl-formamide / 12 h / 100 °C

6.1: 2,6-dimethylpyridine / dichloromethane / 2 h / Cooling with ice

With 2,6-dimethylpyridine; tetrabutyl ammonium fluoride; water; potassium carbonate; caesium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; lithium hydroxide; In tetrahydrofuran; dichloromethane; acetic acid butyl ester; water; N,N-dimethyl-formamide;

Reference yield:

: 1614251-42-1
methyl 4-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)butanoate

: 1614251-45-4
5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-1,2,3,4,7,8-hexahydropyrimido[4,5-a]indolizin-10-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C

1.2: pH 1

2.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / N,N-dimethyl-formamide / 12 h / 100 °C

3.1: 2,6-dimethylpyridine / dichloromethane / 2 h / Cooling with ice

With 2,6-dimethylpyridine; water; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; lithium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;