3β-hydroxy-5-en-7'-(4-methoxyphenyl)-androstano[17,16-d][1,2,4]triazolo[1,5-a]pyrimidine

Base Information

• Chemical Name: 3β-hydroxy-5-en-7'-(4-methoxyphenyl)-androstano[17,16-d][1,2,4]triazolo[1,5-a]pyrimidine
• CAS No.: 1369581-65-6
• Molecular Formula: C₂₉H₃₄N₄O₂
• Molecular Weight: 470.615
• Mol file: 1369581-65-6.mol

Synonyms:3β-hydroxy-5-en-7'-(4-methoxyphenyl)-androstano[17,16-d][1,2,4]triazolo[1,5-a]pyrimidine

Chemical Property of 3β-hydroxy-5-en-7'-(4-methoxyphenyl)-androstano[17,16-d][1,2,4]triazolo[1,5-a]pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3β-hydroxy-5-en-7'-(4-methoxyphenyl)-androstano[17,16-d][1,2,4]triazolo[1,5-a]pyrimidine

There total 2 articles about 3β-hydroxy-5-en-7'-(4-methoxyphenyl)-androstano[17,16-d][1,2,4]triazolo[1,5-a]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

3(5)-amino-1,2,4-triazole (61-82-5) + 3β-hydroxy-16-(4-methoxybenzylidene)-5-androsten-17-one (986-41-4) → 3β-hydroxy-5-en-7'-(4-methoxyphenyl)-androstano[17,16-d][1,2,4]triazolo[1,5-a]pyrimidine (1369581-65-6)

Guidance literature:

With potassium tert-butylate; In butan-1-ol; for 30h; Reflux;

DOI:10.1016/j.steroids.2011.12.012

Reference yield:

dehydroepiandrosterone (53-43-0) + 4-methoxy-benzaldehyde (123-11-5) → 3β-hydroxy-5-en-7'-(4-methoxyphenyl)-androstano[17,16-d][1,2,4]triazolo[1,5-a]pyrimidine (1369581-65-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium fluoride supported on alumina / ethanol / 1 h / Reflux

2: potassium tert-butylate / butan-1-ol / 30 h / Reflux

With potassium tert-butylate; In ethanol; butan-1-ol; 1: Aldol condensation;

DOI:10.1016/j.steroids.2011.12.012

upstream raw materials:

3⁽⁵⁾-amino-1,2,4-triazole

3β-hydroxy-16-(4-methoxybenzylidene)-5-androsten-17-one

dehydroepiandrosterone

4-methoxy-benzaldehyde