3-(tert-butyldimethylsilyloxymethyl)-4-(2-phenylimidazol-1-yl)butanoyl hydrazide

Base Information

Chemical Name:3-(tert-butyldimethylsilyloxymethyl)-4-(2-phenylimidazol-1-yl)butanoyl hydrazide
CAS No.:791856-56-9
Molecular Formula:C₂₀H₃₂N₄O₂Si
Molecular Weight:388.585
Hs Code.:

Synonyms:3-(tert-butyldimethylsilyloxymethyl)-4-(2-phenylimidazol-1-yl)butanoyl hydrazide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(tert-butyldimethylsilyloxymethyl)-4-(2-phenylimidazol-1-yl)butanoyl hydrazide

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Technology Process of 3-(tert-butyldimethylsilyloxymethyl)-4-(2-phenylimidazol-1-yl)butanoyl hydrazide

There total 6 articles about 3-(tert-butyldimethylsilyloxymethyl)-4-(2-phenylimidazol-1-yl)butanoyl hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 791856-93-4
methyl 3-(tert-butyldimethylsilyloxymethyl)-4-(2-phenylimidazol-1-yl)butanoate

: 791856-56-9
3-(tert-butyldimethylsilyloxymethyl)-4-(2-phenylimidazol-1-yl)butanoyl hydrazide

Guidance literature:: With hydrazine; In ethanol;
DOI:10.1021/jo040193z

Reference yield:

: 80904-75-2
4-hydroxymethyl-5H-furan-2-one

: 791856-56-9
3-(tert-butyldimethylsilyloxymethyl)-4-(2-phenylimidazol-1-yl)butanoyl hydrazide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 99 percent / H₂ / Pd/C / methanol / 4 h / 20 °C / atmospheric pressure

2.1: 95 percent / imidazole / dimethylformamide / 13 h / 0 - 20 °C

3.1: KH

3.2: 76 percent / 3 h / 160 - 170 °C

4.1: DMAP / CH₂Cl₂ / 0.5 h / 0 °C

4.2: 80 percent / EDCI / CH₂Cl₂ / 5 h / 0 - 20 °C

5.1: 99 percent / NH₂NH₂ / ethanol

With 1H-imidazole; dmap; hydrogen; potassium hydride; hydrazine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo040193z

Reference yield:

: 36679-81-9
4-hydroxymethyl-1,2,3,4-tetrahydrofuran-2-one

: 791856-56-9
3-(tert-butyldimethylsilyloxymethyl)-4-(2-phenylimidazol-1-yl)butanoyl hydrazide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / imidazole / dimethylformamide / 13 h / 0 - 20 °C

2.1: KH

2.2: 76 percent / 3 h / 160 - 170 °C

3.1: DMAP / CH₂Cl₂ / 0.5 h / 0 °C

3.2: 80 percent / EDCI / CH₂Cl₂ / 5 h / 0 - 20 °C

4.1: 99 percent / NH₂NH₂ / ethanol

With 1H-imidazole; dmap; potassium hydride; hydrazine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo040193z