5-phenyl-3-(2-tert-butyldimethylsilyloxymethyl-3-(2-phenylimidazol-1-yl)propyl)-1,2,4-triazine

Base Information

Chemical Name:5-phenyl-3-(2-tert-butyldimethylsilyloxymethyl-3-(2-phenylimidazol-1-yl)propyl)-1,2,4-triazine
CAS No.:791856-61-6
Molecular Formula:C₂₈H₃₅N₅OSi
Molecular Weight:485.704
Hs Code.:

Synonyms:5-phenyl-3-(2-tert-butyldimethylsilyloxymethyl-3-(2-phenylimidazol-1-yl)propyl)-1,2,4-triazine

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Chemical Property of 5-phenyl-3-(2-tert-butyldimethylsilyloxymethyl-3-(2-phenylimidazol-1-yl)propyl)-1,2,4-triazine

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Technology Process of 5-phenyl-3-(2-tert-butyldimethylsilyloxymethyl-3-(2-phenylimidazol-1-yl)propyl)-1,2,4-triazine

There total 7 articles about 5-phenyl-3-(2-tert-butyldimethylsilyloxymethyl-3-(2-phenylimidazol-1-yl)propyl)-1,2,4-triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1074-12-0
phenylglyoxal hydrate

: 791856-56-9
3-(tert-butyldimethylsilyloxymethyl)-4-(2-phenylimidazol-1-yl)butanoyl hydrazide

: 791856-61-6
5-phenyl-3-(2-tert-butyldimethylsilyloxymethyl-3-(2-phenylimidazol-1-yl)propyl)-1,2,4-triazine

Guidance literature:: With bromobenzene; ammonium acetate; for 6h; Heating;
DOI:10.1021/jo040193z

Reference yield:

: 80904-75-2
4-hydroxymethyl-5H-furan-2-one

: 791856-61-6
5-phenyl-3-(2-tert-butyldimethylsilyloxymethyl-3-(2-phenylimidazol-1-yl)propyl)-1,2,4-triazine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 99 percent / H₂ / Pd/C / methanol / 4 h / 20 °C / atmospheric pressure

2.1: 95 percent / imidazole / dimethylformamide / 13 h / 0 - 20 °C

3.1: KH

3.2: 76 percent / 3 h / 160 - 170 °C

4.1: DMAP / CH₂Cl₂ / 0.5 h / 0 °C

4.2: 80 percent / EDCI / CH₂Cl₂ / 5 h / 0 - 20 °C

5.1: 99 percent / NH₂NH₂ / ethanol

6.1: 31 percent / NH₄OAc / 1,2-dichloro-benzene / 0.1 h / 195 °C / microwave irradiation

With 1H-imidazole; dmap; ammonium acetate; hydrogen; potassium hydride; hydrazine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 1,2-dichloro-benzene;
DOI:10.1021/jo040193z

Reference yield:

: 36679-81-9
4-hydroxymethyl-1,2,3,4-tetrahydrofuran-2-one

: 791856-61-6
5-phenyl-3-(2-tert-butyldimethylsilyloxymethyl-3-(2-phenylimidazol-1-yl)propyl)-1,2,4-triazine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 95 percent / imidazole / dimethylformamide / 13 h / 0 - 20 °C

2.1: KH

2.2: 76 percent / 3 h / 160 - 170 °C

3.1: DMAP / CH₂Cl₂ / 0.5 h / 0 °C

3.2: 80 percent / EDCI / CH₂Cl₂ / 5 h / 0 - 20 °C

4.1: 99 percent / NH₂NH₂ / ethanol

5.1: 31 percent / NH₄OAc / 1,2-dichloro-benzene / 0.1 h / 195 °C / microwave irradiation

With 1H-imidazole; dmap; ammonium acetate; potassium hydride; hydrazine; In ethanol; dichloromethane; N,N-dimethyl-formamide; 1,2-dichloro-benzene;
DOI:10.1021/jo040193z