Propanenitrile, 3-[(4-fluorophenyl)amino]- (9CI)

Base Information

• Chemical Name: Propanenitrile, 3-[(4-fluorophenyl)amino]- (9CI)
• CAS No.: 380190-11-4
• Molecular Formula: C₉H₉FN₂
• Molecular Weight: 164.182
• Mol file: 380190-11-4.mol

Synonyms:NSC 314008

Chemical Property of Propanenitrile, 3-[(4-fluorophenyl)amino]- (9CI)

Chemical Property:

• PSA: 35.82000
• LogP: 2.22428

Purity/Quality:

3-[(4-fluorophenyl)amino]propanenitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanenitrile, 3-[(4-fluorophenyl)amino]- (9CI)

There total 1 articles about Propanenitrile, 3-[(4-fluorophenyl)amino]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

acrylonitrile (107-13-1,25014-41-9) + 4-fluoroaniline (371-40-4) → 3-((4-fluorophenyl)amino)propanenitrile (380190-11-4)

Guidance literature:

4-fluoroaniline; With potassium tert-butylate; copper(l) chloride; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride; In toluene; for 0.333333h; Inert atmosphere;

acrylonitrile; In toluene; at 22 ℃; for 15h; Inert atmosphere;

DOI:10.1021/acs.joc.6b00341

upstream raw materials:

acrylonitrile

4-fluoroaniline

Refernces

• 1、 Kour, Manmeet,Paul, Satya. "A green and convenient approach for the one-pot solvent-free synthesis of coumarins and β-amino carbonyl compounds using Lewis acid grafted sulfonated carbon@titania composite". . p. 327 - 337. Retrieved 2017/02/10.
• 2、 Damera, Krishna,Reddy, Katta L.,Sharma, Gangavaram V.M.. "An efficient ZrCl4 catalyzed aza-michael addition reaction: Synthesis of C-linked carbo β3-amino acids". experimental part. p. 151 - 155. Retrieved 2010/04/23.