Technology Process of ethyl (2S,4S,6S)-6-[[(2S,4S,6S)-6-methyl-2-phenyl-1,3-dioxan-4-yl]methyl]-2-phenyl-1,3-dioxane-4-acetate
There total 8 articles about ethyl (2S,4S,6S)-6-[[(2S,4S,6S)-6-methyl-2-phenyl-1,3-dioxan-4-yl]methyl]-2-phenyl-1,3-dioxane-4-acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium tert-butylate;
In
tetrahydrofuran;
at 0 - 20 ℃;
DOI:10.1021/ol0345529
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 230 mg / LiCl; i-Pr2NEt / acetonitrile / 20 °C
2.1: 90 percent / Sm(OiPr)3; 4 Angstroem molecular sieves; AsPh3O / (S)-BINOL; tert-butyl hydroperoxide / tetrahydrofuran; decane / 8 h / 20 °C
3.1: LHMDS / tetrahydrofuran / 0.42 h / -78 °C
3.2: 88 percent / tetrahydrofuran / 4 h / -78 °C
4.1: 77 percent / NaBH4; PhSeSePh / ethanol / 0.08 h / 20 °C
5.1: Et2B(OMe) / tetrahydrofuran; methanol / 1 h / -78 °C
5.2: NaBH4 / tetrahydrofuran; methanol / 8 h / -78 - -40 °C
6.1: 246 mg / TsOH*H2O / toluene / 20 °C
With
sodium tetrahydroborate; 4 A molecular sieve; diphenyl diselenide; diethyl methoxy borane; triphenylarsineoxide; samarium(III) isopropoxide; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; lithium chloride; lithium hexamethyldisilazane;
tert.-butylhydroperoxide; (S)-[1,1']-binaphthalenyl-2,2'-diol;
In
tetrahydrofuran; methanol; decane; ethanol; toluene; acetonitrile;
DOI:10.1002/chem.200305709
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 180 mg / N-methylmorpholine-N-oxide; 4 Angstroem molecular sieves; TPAP / CH2Cl2 / 1 h / 20 °C
2.1: 230 mg / LiCl; i-Pr2NEt / acetonitrile / 20 °C
3.1: 90 percent / Sm(OiPr)3; 4 Angstroem molecular sieves; AsPh3O / (S)-BINOL; tert-butyl hydroperoxide / tetrahydrofuran; decane / 8 h / 20 °C
4.1: LHMDS / tetrahydrofuran / 0.42 h / -78 °C
4.2: 88 percent / tetrahydrofuran / 4 h / -78 °C
5.1: 77 percent / NaBH4; PhSeSePh / ethanol / 0.08 h / 20 °C
6.1: Et2B(OMe) / tetrahydrofuran; methanol / 1 h / -78 °C
6.2: NaBH4 / tetrahydrofuran; methanol / 8 h / -78 - -40 °C
7.1: 246 mg / TsOH*H2O / toluene / 20 °C
With
sodium tetrahydroborate; tetrapropylammonium perruthennate; 4 A molecular sieve; diphenyl diselenide; diethyl methoxy borane; triphenylarsineoxide; samarium(III) isopropoxide; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; lithium chloride; lithium hexamethyldisilazane;
tert.-butylhydroperoxide; (S)-[1,1']-binaphthalenyl-2,2'-diol;
In
tetrahydrofuran; methanol; decane; ethanol; dichloromethane; toluene; acetonitrile;
DOI:10.1002/chem.200305709
