188924-70-1

Upstream product

• 100-52-7 benzaldehyde 
• 91326-80-6 Methyl (S,E)-5-Hydroxyhex-2-enoate 
• 188924-79-0 (2S,4S,6S)-4-(carboethoxymethyl)-2-methyl-6-phenyl-1,3-dioxane 
• 695177-27-6 2-((2S,4R,6S)-6-Methyl-2-phenyl-[1,3]dioxan-4-yl)-ethanol 

Downstream Products

• 361521-37-1 (2S,4S,6S)-4-(2-hydroxypent-4-enyl)-2-methyl-6-phenyl-1,3-dioxane 
• 361521-44-0 (2S,4S,6S)-4-(2-hydroxypent-4-enyl)-2-methyl-6-phenyl-1,3-dioxane 
• 695177-08-3 4-[(E)-4-[(2S,4R,6S)-6-methyl-2-phenyl-1,3-dioxan-4-yl]-1-oxo-2-butenyl]morpholine 
• 188924-72-3 (R)-6-(tert-Butyl-diphenyl-silanyloxy)-1-((2S,4S,6S)-6-methyl-2-phenyl-[1,3]dioxan-4-yl)-heptane-2,4-dione 
• 188924-81-4 (R)-6-Hydroxy-1-((2S,4S,6S)-6-methyl-2-phenyl-[1,3]dioxan-4-yl)-heptane-2,4-dione 
• 361521-39-3 Acrylic acid (R)-1-((2S,4S,6S)-6-methyl-2-phenyl-[1,3]dioxan-4-ylmethyl)-but-3-enyl ester 
• 361521-41-7 Acrylic acid (S)-1-((2S,4S,6S)-6-methyl-2-phenyl-[1,3]dioxan-4-ylmethyl)-but-3-enyl ester 
• 361521-40-6 (R)-6-((2S,4S,6S)-6-Methyl-2-phenyl-[1,3]dioxan-4-ylmethyl)-5,6-dihydro-pyran-2-one 
• 361521-42-8 (S)-6-((2S,4S,6S)-6-Methyl-2-phenyl-[1,3]dioxan-4-ylmethyl)-5,6-dihydro-pyran-2-one 
• 695177-10-7 ethyl (Z)-4-[(2R,4R,6R)-6-[[(2S,4S,6S)-6-methyl-2-phenyl-1,3-dioxan-4-yl]methyl]-2-phenyl-1,3-dioxan-4-yl]-2-butenoate 
• 695177-30-1 (3S,5R)-3,5-Dihydroxy-6-((2S,4R,6S)-6-methyl-2-phenyl-[1,3]dioxan-4-yl)-hexanoic acid ethyl ester 
• 695177-09-4 4-[(2R,3S)-2,3-epoxy-4-[(2S,4R,6S)-6-methyl-2-phenyl-1,3-dioxan-4-yl]-1-oxobutyl]morpholine 
• 695177-29-8 ethyl (4R,5S)-4,5-epoxy-6-[(2S,4R,6S)-6-methyl-2-phenyl-1,3-dioxan-4-yl]-3-oxohexanoate 
• 549513-47-5 ethyl (2S,4S,6S)-6-[[(2S,4S,6S)-6-methyl-2-phenyl-1,3-dioxan-4-yl]methyl]-2-phenyl-1,3-dioxane-4-acetate 

Relevant academic research and scientific papers

Synthesis of γ- and δ-lactone natural products by employing a trans-cis isomerization/lactonization strategy

Alkaline hydrolysis of 4-hydroxy- or/and 5-hydroxy-(2E)-alkenoate followed by acid treatment gave the corresponding (2E)-alkenoic acids which were subjected to lactone formation reaction without further purification. The crude acids were treated with 2,4,6-trichlorobenzoyl chloride in pyridine to afford ?-lactone or d-lactone, respectively, accompanied by trans-cis isomerization. By this procedure, (±)-(4,5)-trans-5-benzyloxy- 2-hexen-4-olide (90% overall yield), (S)-5-hydroxy-2-penten-4-olide (86% overall yield), (4S,5R)-5- hydroxy-2-hexen-4-olide (86% overall yield), (4R,5S)-5-hydroxy-2-hexen-4-olide (82% overall yield), (S)- parasorbic acid (58% overall yield) and natural product, (5R,7S)-7-hydroxy-2-octen-5-olide (euscapholide: 20% overall yield) were synthesized.

Strategy for Enantio- and Diastereoselective Syntheses of All Possible Stereoisomers of 1,3-Polyol Arrays Based on a Highly Catalyst-Controlled Epoxidation of α,β-Unsaturated Morpholinyl Amides: Application to Natural Product Synthesis

We describe a new strategy for enantio- and diastereoselective syntheses of all possible stereoisomers of 1,3-polyol arrays. This strategy relies on a highly catalyst-controlled epoxidation of α,β-unsaturated morpholinyl amides promoted by the Sm-BINOL-Ph

Enantioselective syntheses of cryptocarya triacetate, Cryptocaryolone, and cryptocaryolone diacetate

(Matrix presented) The enantioselective syntheses of three natural products from Cryptocarya latifolia have been achieved in 13-15 steps from ethyl sorbate. The route relies upon an enantio- and regioselective Sharpless dihydroxylation and a palladium-cat

An enantioselective synthesis of cryptocarya diacetate

(Equation presented) The enantioselective synthesis of cryptocarya diacetate has been achieved in 10 steps from ethyl sorbate. The route relies upon an enantio- and regioselective Sharpless dihydroxylation and a palladium-catalyzed reduction to form a δ-h