2-[4-(3-Amino-4-nitrophenyl)piperazin-1-yl]ethan-1-ol

Base Information

Chemical Name:2-[4-(3-Amino-4-nitrophenyl)piperazin-1-yl]ethan-1-ol
CAS No.:23470-44-2
Molecular Formula:C₁₂H₁₈N₄O₃
Molecular Weight:266.3
Hs Code.:
DSSTox Substance ID:DTXSID201253505

Synonyms:23470-44-2;2-[4-(3-amino-4-nitrophenyl)piperazin-1-yl]ethan-1-ol;2-[4-(3-amino-4-nitrophenyl)piperazin-1-yl]ethanol;2-(4-(3-Amino-4-nitrophenyl)piperazin-1-yl)ethanol;2-(4-(3-Amino-4-nitrophenyl)piperazin-1-yl)ethan-1-ol;2-[4-(3-Amino-4-nitro-phenyl)-piperazin-1-yl]-ethanol;SCHEMBL2553773;MAGAFWCADCQCEJ-UHFFFAOYSA-N;DTXSID201253505;MFCD00545981;AKOS000439520;AS-2771;CS-0449993;4-(3-Amino-4-nitrophenyl)-1-piperazineethanol;2-[4-(3-Amino-4-nitrophenyl)-piperazin-1-yl]ethan-1-ol

Suppliers and Price of 2-[4-(3-Amino-4-nitrophenyl)piperazin-1-yl]ethan-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 2-[4-(3-Amino-4-nitrophenyl)piperazin-1-yl]ethan-1-ol

Chemical Property:

XLogP3:0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:266.13789045
Heavy Atom Count:19
Complexity:302

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCN1CCO)C2=CC(=C(C=C2)[N+](=O)[O-])N

Technology Process of 2-[4-(3-Amino-4-nitrophenyl)piperazin-1-yl]ethan-1-ol

There total 1 articles about 2-[4-(3-Amino-4-nitrophenyl)piperazin-1-yl]ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 1635-61-6
5-chloro-2-nitroaniline

: 23470-44-2
2-(4-(3-amino-4-nitrophenyl)piperazin-1-yl)ethan-1-ol

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jm500427n

Reference yield: 100.0%

: 23470-44-2
2-(4-(3-amino-4-nitrophenyl)piperazin-1-yl)ethan-1-ol

: 485841-41-6
4-[4-(2-hydroxyethyl)piperazin-1-yl]-benzene-1,2-diamine

Guidance literature:: With palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃; for 24h;
DOI:10.1039/c5ob00675a

Reference yield:

: 23470-44-2
2-(4-(3-amino-4-nitrophenyl)piperazin-1-yl)ethan-1-ol

: 23617-83-6
2-{4-[2-(3,4-diamino-phenyl)-1⁽³⁾H-benzoimidazol-5-yl]-piperazin-1-yl}-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen; acetic acid / 5%-palladium/activated carbon / ethanol / 24 h / 20 °C / Inert atmosphere

1.2: 24 h / 80 °C / Inert atmosphere

1.3: 24 h / 4 °C

2.1: hydrogen / 5%-palladium/activated carbon / ethyl acetate; methanol / 24 h / 20 °C / Inert atmosphere

With hydrogen; acetic acid; 5%-palladium/activated carbon; In methanol; ethanol; ethyl acetate;