4-amino-6-phenyl-1-methyl-2-pyrimidinethione

Base Information

• Chemical Name: 4-amino-6-phenyl-1-methyl-2-pyrimidinethione
• CAS No.: 158495-65-9
• Molecular Formula: C₁₁H₁₁N₃S
• Molecular Weight: 217.294
• Mol file: 158495-65-9.mol

Synonyms:4-amino-6-phenyl-1-methyl-2-pyrimidinethione

Chemical Property of 4-amino-6-phenyl-1-methyl-2-pyrimidinethione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-amino-6-phenyl-1-methyl-2-pyrimidinethione

There total 2 articles about 4-amino-6-phenyl-1-methyl-2-pyrimidinethione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

S-methylthiourea + β-methoxy-cinnamonitrile (73591-17-0) → 4-amino-6-phenyl-1-methyl-2-pyrimidinethione (158495-65-9)

Guidance literature:

With sodium ethanolate; In N,N-dimethyl-formamide;

Reference yield:

β-ethoxy-cinnamonitrile (872276-59-0) + 1-(methyl)-thiourea (598-52-7) → 4-amino-6-phenyl-1-methyl-2-pyrimidinethione (158495-65-9)

Guidance literature:

With sodium ethanolate; In ethanol; for 24h; Heating;

DOI:10.1021/jm00048a018

Reference yield:

4-amino-6-phenyl-1-methyl-2-pyrimidinethione (158495-65-9) → C28H28N8O7S3

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylformamide / 1 h / Ambient temperature

2: CF₃COOH, anisole / 3 h / 30 °C

With methoxybenzene; trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.1021/jm00048a018

upstream raw materials:

β-ethoxy-cinnamonitrile

1-(methyl)-thiourea

β-methoxy-cinnamonitrile

Refernces

• 1、 -. "Novel cephalosporin compounds and processes for the preparation thereof". . . Retrieved 2008/06/13.