benzyl 2-(acetoxy(phenyl)methyl)buta-2,3-dienoate

Base Information

• Chemical Name: benzyl 2-(acetoxy(phenyl)methyl)buta-2,3-dienoate
• CAS No.: 1257228-78-6
• Molecular Formula: C₂₀H₁₈O₄
• Molecular Weight: 322.361
• Mol file: 1257228-78-6.mol

Synonyms:benzyl 2-(acetoxy(phenyl)methyl)buta-2,3-dienoate

Chemical Property of benzyl 2-(acetoxy(phenyl)methyl)buta-2,3-dienoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 2-(acetoxy(phenyl)methyl)buta-2,3-dienoate

There total 2 articles about benzyl 2-(acetoxy(phenyl)methyl)buta-2,3-dienoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

benzyl 2-(hydroxy-(phenyl)methyl)buta-2,3-dienoate + acetyl chloride (75-36-5) → benzyl 2-(acetoxy(phenyl)methyl)buta-2,3-dienoate (1257228-78-6)

Guidance literature:

benzyl 2-(hydroxy-(phenyl)methyl)buta-2,3-dienoate; With pyridine; In dichloromethane; at -5 ℃; for 0.0833333h;

acetyl chloride; In dichloromethane; for 0.833333h;

DOI:10.1021/acs.joc.1c01137

Reference yield:

benzaldehyde (100-52-7) → benzyl 2-(acetoxy(phenyl)methyl)buta-2,3-dienoate (1257228-78-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tin(ll) chloride; sodium iodide / 6 h / 20 °C / Darkness

1.2: 0 - 20 °C

2.1: pyridine / dichloromethane / 1 h / 0 °C

With pyridine; sodium iodide; tin(ll) chloride; In dichloromethane;

DOI:10.1021/jacs.6b04935

Reference yield: 94.0%

benzyl 2-(acetoxy(phenyl)methyl)buta-2,3-dienoate (1257228-78-6) + Benzoylacetonitrile (614-16-4) → C27H21NO3

Guidance literature:

With C₃₅H₄₄N₄O₃; sodium carbonate; In ethyl acetate; at 0 ℃; for 32h; enantioselective reaction; Schlenk technique;

DOI:10.1021/jacs.6b04935

upstream raw materials:

benzaldehyde

acetyl chloride

Downstream raw materials:

C₂₇H₂₁NO₃

benzyl 3-tert-butyl-4-oxo-1,6-diphenyl-2,3-diazaspiro[4.4]nona-1,7-diene-7-carboxylate